An UPLC-MS/MS Method for Determination of Osimertinib in Rat Plasma: Application to Investigating the Effect of Ginsenoside Rg3 on the Pharmacokinetics of Osimertinib

Table 1

General mass spectrometric settings for the osimertinib and internal standards.

Analytes	m/z (Q1 ⟶  Q3)	ESI	RT (min)	DP (V)	EP (V)	CE (V)	CXP (V)
Osimertinib	m/z 500.3 ⟶ m/z 427.4	+	2.51	95	10	34	16
Nilotinib (IS)	m/z 530.1 ⟶ m/z 289.1	+	2.90	150	10	40	7