An UPLC-MS/MS Method for Determination of Osimertinib in Rat Plasma: Application to Investigating the Effect of Ginsenoside Rg3 on the Pharmacokinetics of Osimertinib

Table 3

Intraday and interday precision and accuracy of osimertinib in rat plasma.

Analytes	Spiked concentration (ng/mL)	Intraday (n = 6)			Interday (n = 18)
		Mean ± SD (ng/mL)	RSD (%)	Accuracy (%)	Mean ± SD (ng/mL)	RSD (%)	Accuracy (%)
Osimertinib	1 (LLOQ)	1.02 ± 0.11	10.4	102.5	0.99 ± 0.10	10.3	98.5
	3 (QC-L)	2.94 ± 0.20	6.9	98.1	2.91 ± 0.20	6.8	97.0
	30 (QC-M)	31.0 ± 0.5	1.7	103.2	30.3 ± 1.6	5.2	101.1
	350 (QC-H)	368 ± 11	3.1	105.1	365 ± 13	3.5	104.3