A Validated Method for the Simultaneous Determination of Methamphetamine and 3,4-Methylenedioxy-N-methamphetamine in Blood-Based Liquid Chromatography-Tandem Mass Spectrometry

Table 2

Characterization of analytes by GC-MS/MS.

Analytes	Retention time (min)	Scan time (s)	Precursor ion (m/z)	MRM transition, m/z (collision energy, V)
				Quantification	Confirmation
Methamphetamine	0.414–0.478	0.8	150	150 > 91(13)	150 > 119 (5)
3,4-Methylenedioxy-N-methamphetamine	0.401–0.469	0.7	194	194 > 163 (9)	194 > 105 (25)
Methamphetamine–d5	0.407–0.476	0.8	155	155 > 96 (13)	155 > 124 (9)
3,4-Methylenedioxy-N-methamphetamine-d5	0.409–0.435	0.7	199	199 > 165 (9)	199 > 107 (21)