Analytical Quality by Design Approach of Reverse-Phase High-Performance Liquid Chromatography of Atorvastatin: Method Development, Optimization, Validation, and the Stability-Indicated Method

<table class="table-group" id="tab5"><tr><td><table class="table"><tr><td class="thead-hr" colspan="8"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Quality control sample</td><td class="align_center" rowspan="2">Concentration (<i>μ</i>g/ml)</td><td class="align_center" colspan="3">Intraday precision and accuracy</td><td class="align_center" colspan="3">Interday precision and accuracy</td></tr><tr class="thead"><td class="align_center">Experimental concentration</td><td class="align_center">% RSD</td><td class="align_center">Accuracy</td><td class="align_center">Experimental concentration</td><td class="align_center">% RSD</td><td class="align_center">Accuracy</td></tr><tr><td class="thead-hr" colspan="8"><hr/></td></tr><tr><td class="align_left">LQC</td><td class="align_center">1.5</td><td class="align_center">1.48 ± 0.04</td><td class="align_center">2.70</td><td class="align_center">98.66 ± 2.9</td><td class="align_center">1.475 ± 0.04</td><td class="align_center">2.71</td><td class="align_center">98.33 ± 2.46</td></tr><tr><td class="align_left">MQC</td><td class="align_center">12.44</td><td class="align_center">12.42 ± 0.3</td><td class="align_center">2.41</td><td class="align_center">99.84 ± 2.1</td><td class="align_center">12.43 ± 0.3</td><td class="align_center">2.41</td><td class="align_center">98.91 ± 2.33</td></tr><tr><td class="align_left">HQC</td><td class="align_center">24</td><td class="align_center">23.96 ± 0.43</td><td class="align_center">1.79</td><td class="align_center">99.83 ± 1.8</td><td class="align_center">23.94 ± 0.3</td><td class="align_center">1.25</td><td class="align_center">99.75 ± 1.41</td></tr><tr class="table-tr"><td colspan="8"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Precision and accuracy of different quality control samples of ATS.</div>

International Journal of Analytical Chemistry

tab5

Table 5

Table 5: Analytical Quality by Design Approach of Reverse-Phase High-Performance Liquid Chromatography of Atorvastatin: Method Development, Optimization, Validation, and the Stability-Indicated Method 

Table 5 | Analytical Quality by Design Approach of Reverse-Phase High-Performance Liquid Chromatography of Atorvastatin: Method Development, Optimization, Validation, and the Stability-Indicated Method 