Determination and Pharmacokinetics of Omeprazole Enantiomers in Human Plasma and Oral Fluid Utilizing Microextraction by Packed Sorbent and Liquid Chromatography-Tandem Mass Spectrometry

Table 2

Determination of OME with different methods.

Method	Linear range (ng/mL)	Matrix (OM form)	Sample preparation method	Extraction efficiency (%)	Ref.
RP-HPLC	2–2000	Human plasma (racemate)	LLE	84	[10]
HILIC-MS/MS	2–1000	Human plasma (racemate)	LLE	87–98	[11]
UHPLC-MS/MS	10–500	Rat plasma (racemate)	Protein precipitation and LLE	87	[36]
LC-UV	50–1000	Human plasma (enantiomers)	SPE	93–94	[37]
LC-MS/MS	1.25–2500	Human plasma (enantiomers)	Protein precipitation (PP)	105–106	[38]
LC-MS/MS	25–500	Human plasma, oral fluid (enantiomers)	MEPS	94–98	Present study