HPLC-MS/MS-Mediated Analysis of the Pharmacokinetics, Bioavailability, and Tissue Distribution of Schisandrol B in Rats

Table 5

Pharmacokinetic parameters of Schisandrol B in rat plasma.

Parameters	Schisandrol B		SCE
	Group 1 (2 mg/kg; iv)	Group 2 (10 mg/kg; ig)	Group 3 (6 mL/kg; ig)
t1/2 (h)	1.10 ± 0.10	1.59 ± 1.42	2.55 ± 0.66
CL (L/h/kg)	4.38 ± 1.12	23.37 ± 3.25	6.43 ± 1.83
MRT0-∞ (h)	0.67 ± 0.01	3.31 ± 0.46	9.09 ± 1.51
Tmax (h)	—	0.54 ± 0.40	2.00 ± 0.87
Cmax (ng/mL)	—	133.09 ± 18.71	288.67 ± 67.47
AUC0-t (ng.h/mL)	456.68 ± 91.24	426.22 ± 32.64	2288.87 ± 276.44
AUC0-∞ (ng.h/mL)	456.84 ± 91.63	427.93 ± 33.15	2334.08 ± 381.07
F (%)	—	18.73	68.12