Nanoparticulate Radiolabelled Quinolines Detect Amyloid Plaques in Mouse Models of Alzheimer's Disease

Table 1

In vivo biodistribution of ¹²⁵I-CQ by IV administration in wild type mice (𝑛=105) (table represents organ uptakes in %ID/g ± SD).

Time (min)	Brain	Blood	Spleen	Liver	Brain∶blood ratio
2	1±0.4	9.2±2.8	2.6±0.1	12.5±0.8	0.1±0.1
5	1±0.3	5.7±1.3	N/A	15.5±5.6	0.2±0.01
15	0.3±0.1	2.9±0.7	1.2±0.1	3.8±0.7	0.1±0.1
30	0.3±0.1	2.3±0.4	1.3±1	5.2±2.2	0.1±0.1
60	0.1±0.1	1.3±0.7	0.5±0.3	3.6±2.3	0.3±0.5
120	0.03±0.03	0.1±0.1	0.6±0.4	1.3±0.5	0.2±0.1
240	0.04±0.02	0.6±0.2	0.4±0.3	0.9±0.2	0.1±0.1

𝑃=.05