Amyloid Beta Annular Protofibrils in Cell Processes and Synapses Accumulate with Aging and Alzheimer-Associated Genetic Modification
Figure 2
Ultrastructural localization of annular protofibrils (APFs) in aged (a,c) and (b,d–f) mouse brain sections. DAB method. (a) Anti-annular protofibril immunoreactions (APF-IRs) on synaptic vesicles in axon terminal (AT) and vesicles in axon (Ax). Den: dendrite, Glia: glial process, and Mit: mitochondria. (b,c) APF-IRs on plasma membranes of dendrite (b) and unidentified process (UN) (c). (d) APF-IR on postsynaptic density (PSD). (e,f) APF-IRs were observed on plasma membranes and vesicles inside of cell processes (arrows) in senile plaques, but not on amyloid fibrils (Fib) and distended neurites (DN). Scale bar = 200 nm.
