Trial Designs Likely to Meet Valid Long-Term Alzheimer's Disease Progression Effects: Learning from the Past, Preparing for the Future

Figure 2

Hypothetical trajectories depicting the changes in level of functioning across time that would be expected due to the natural progression of AD, or with other conceptualized interventions that would produce a symptomatic relief, a disease modifying effect, stabilization, improvement (neurorestoration), or prevention, respectively. Image used with the permission of its creator, Rachel Schindler (Pfizer, Inc.).