Mitochondria, Cognitive Impairment, and Alzheimer's Disease

Figure 1

A proposed mechanism of mitochondrial induced cell death in Alzheimer’s disease . Legend: A𝛽; amyloid-𝛽; ROS reactive oxygen species; ETC electron transport chain; mtPTP mitochondrial permeability transition pore; C cytochrome c ; IMM inner mitochondrial membrane; OMM outer mitochondrial membrane; APP amyloid precursor protein; TOM and TIM protein importation translocases of the mitochondrial outer and inner membranes. For further details, see text. (Modified from Mancuso M et al., Antioxid Redox Signal 2007;9:1631–1646).