Neuroprotective Effects of Centella asiatica against Intracerebroventricular Colchicine-Induced Cognitive Impairment and Oxidative Stress

Table 2

Effect of Centella asiatica (CA; 150 and 300 mg/kg, PO) on memory performance in elevated plus maze paradigm in intracerebroventricular colchicines- (COL-) injected rats.

Treatment (mg/kg)	Mean transfer latency (in seconds)
	ITL	1st RTL	2nd RTL
Sham	58.16±1.79	20.5±4.28	17.0±5.16
ACSF	61.16±1.6	15.66±1.66	12.60±1.49
COL	66.66±1.53^a	79.33±1.33^a	72.33±1.20^a
CA (150)	62.16±1.51	19.16±0.945	13.16±1.16
CA (300)	61.8±1.077	17.16±1.79	10.16±0.844
CA (150) + COL	66.3±1.470	49.33±0.881^b	42.8±0.478^b
CA (300) + COL	62.8±1.238^c	33.6±0.577^b,c	29.44±0.958^b,c

The initial transfer latencies (ITLs) on day 13 and retention transfer latencies on days 14 (1st RTL) and 21 (2nd RTL) following colchicine injection were observed. Values are mean ± SEM; ^a𝑃<.05 as compared to artificial cerebrospinal fluid (ACSF)-injected group; ^b𝑃<.05 as compared to colchicine-injected group; ^c𝑃<.05 as compared to CA (150) + COL group; (repeated measures two-way ANOVA followed by Tukey’s test for multiple comparisons). Note: ACSF: artificial cerebrospinal fluid; COL: colchicine; CA: Centella. asiatica