Research Article

Alzheimer's Disease: A Pathogenetic Autoimmune Disorder Caused by Herpes Simplex in a Gene-Dependent Manner

Table 5

Other viruses expressing homologous proteins for the four major Alzheimer’s disease susceptibility gene products.

Alzheimer’s geneViral proteinIdentical amino acid sequences (vatches)

APOE4
Chain A, Apolipoprotein E4 (Apoe4), 22k Fragment.
ACCESSION 1B68_A
ACE82482 polyprotein Hepatitis C virus subtype 1atab5.1
YP_002455799 tape measure protein Lactobacillus phage Lv-1
ADD95207 hypothetical protein uncultured phage MedDCM-OCT-S04-C650
YP_002242088 gp31 Mycobacterium phage Konstantine
YP_002922735 gp63 Burkholderia phage BcepIL02
NP_612835 major capsid protein Clostridium phage phi3626
AAT07716 virion protein human herpesvirus 3
DAA06495 envelope glycoprotein 24 human herpesvirus 5
YP_001293401 hypothetical protein PPF10_gp057 Pseudomonas phage F10

Clusterin isoform 1
NP_001822.2
ACS93434 capsid portal protein human herpesvirus 5tab5.2
CAA35329 HCMVUL127 human herpesvirus 5
T44166 hypothetical protein U20 imported—human herpesvirus 6 (strain Z29)
AF157706_21 U20 human herpesvirus 6B
P60504ICP47_HSV2S ICP47 protein;
NP_044506 large tegument protein human herpesvirus 2
AAR12147 US34 human herpesvirus 5
AAA66443 unknown protein human herpesvirus 2
D1LR45_9INFA D1LR45 Hemagglutinin Influenza A virus

Clusterin isoform 2
NP_976084.1
ACS93434 capsid portal protein human herpesvirus 5tab5.3
C3U7E2Influenza A virus
C3VE93 Envelope glycoprotein (Fragment) human immunodeficiency virus
D2XAW9 Restriction endonuclease Marseillevirus
Q5J5Q8 Gp46 Mycobacterium phage
Q9DVL9_9HIV1 Q9DVL9 Envelope glycoprotein gp160 human immunodeficiency virus
ORF10 Vibrio phage
Q2PZB7 RstR-like protein Vibrio phage CTX
P36272 Portal protein Enterobacteria phage P21

Clusterin isoform 3
NP_001164609.1
ACS93434 capsid portal protein human herpesvirus 5tab5.4
NP_050200 glycoprotein human herpesvirus 6
NP_050228 glycoprotein O human herpesvirus 6
YP_001129444 BFLF1 human herpesvirus 4 type 2
NP_044506 large tegument protein human herpesvirus 2
AAA66443 unknown protein human herpesvirus 2
D1LR45 Hemagglutinin Influenza A virus

CR1 isoform f
NP_000564.2
ACL67924 single-stranded DNA-binding protein human herpesvirus 3tab5.5
P88903_HHV8 P88903 ORF 4 human herpesvirus 8 type M PE = 4 SV = 1
AAD49671AF157706_89 U79 human herpesvirus 6B
ABI63477 UL15 human herpesvirus 1
CAB06775 UL15 human herpesvirus 2
ACN63150 pUL27 human herpesvirus 5
ACS92020 tegument protein UL14 human herpesvirus 5
NP_042926 protein UL49 human herpesvirus 6
BAA78254 capsid protein human herpesvirus 6B
ABI63477 UL15 human herpesvirus 1
NP_044484 DNA packaging terminase subunit 1 human herpesvirus 2
CAA35376 HCMVUL61 human herpesvirus 5tab5.6
:Q01016-2 Q01016 Isoform 2 of Complement control protein homolog Saimiriine herpesvirus 2
:Q01016-2 Q01016 Isoform 2 of Complement control protein homolog Saimiriine herpesvirus 2 (strain 11)

CR1 isoform S
NP_000642.3
Q2HRD4 ORF4 human herpesvirus 8 type P (isolate GK18)tab5.7
ACL51139 helicase-primase primase subunit human herpesvirus 5
NP_050259 DNA replication human herpesvirus 6
AAD49671AF157706_89 U79 human herpesvirus 6B
AAR84398 ORF_03L Herpes simplex virus 1 strain R-15
CAA58413 U33 human herpesvirus 6
BAA78254 capsid protein human herpesvirus 6B
CAA35376 HCMVUL61 human herpesvirus 5
NP_044484 DNA packaging terminase subunit 1 human herpesvirus 2
NP_042966 DNA replication origin-binding helicase human herpesvirus 6
Q2HRD4 ORF4 human herpesvirus 8 type P (isolate GK18)

PICALM
NP_001008660.1
AAR84403 ORF_08L Herpes simplex virus 1 strain R-15tab5.8
ABX74960 dihydrofolate reductase-like protein Retroperitoneal fibromatosis-associated herpesvirus
CAA32311 very large tegument protein human herpesvirus 1
AAP88252 UL74 protein human herpesvirus 5
ABF22039 DNA polymerase catalytic subunit human herpesvirus 3
BAA86355 polyprotein Hepatitis C virus
NP_899479 hypothetical protein KVP40.0233 Vibrio phage KVP40
ADD94131 hypothetical protein uncultured phage MedDCM-OCT-S04-C1161
NP_671655 EVM136 Ectromelia virus
AAM92151AF436128_1 putative transforming protein E6 human papillomavirus—cand89
YP_002727871 putative structural protein Pseudomonas phage phikF77
AAT73600 minor tail protein Lactococcus phage 943
BAE44071 polyprotein human coxsackievirus A24
ADD25709 putative phage structural protein Lactococcus phage 1358
NP_899479 hypothetical protein KVP40.0233 Vibrio phage KVP40
YP_238567 ORF319 Staphylococcus phage Twort
BAE44071 polyprotein human coxsackievirus A24
YP_002332459 hypothetical protein PPMP29_gp34 Pseudomonas phage MP29