Down's Syndrome with Alzheimer's Disease-Like Pathology: What Can It Teach Us about the Amyloid Cascade Hypothesis?

Table 1

Semiquantitative assessment of AD changes.

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NFTs = Neurofibrillary tangles; expressed as percent of nerve cells affected by NFTs per 400 X field.
Threads = neuropil threads present without NFT.
Amyloid plaque frequency per 100 X field: A=1-4; B=5-9; B+=10-19; C−=20-29; C=30-50; C+=>50.
Vx = amyloid-positive vessels.
— = no data; 0 = absent; ∗large, diffuse plaques in the molecular layer covering ~40% of the area.
Red/yellow shading indicates data pairs with divergent/similar results of cases 1 and 2, respectively.