Review Article

Cerebrospinal Fluid Biomarkers for Dementia with Lewy Bodies

Figure 1

Neuropathological hallmarks of dementia. Senile plaques (a) containing amyloid protein and neurofibrillary pathology (b) consisting of altered tau protein are the hallmarks of Alzheimer’s disease and ageing. In dementia, loss of synaptic proteins affects both allo- and neocortical areas. In Dementia with Lewy body, intraneuronal aggregates of -synuclein give rise to Lewy bodies ((d),(e)) that are also found in normal ageing and in other neurodegenerative diseases, including AD and PDD. Light microscopy ((a), (d)); confocal microscopy ((b), (c), (e)). Labelling: Bielschowsky silver (a), tau immunohistochemistry (b), synaptophysin labelling (c), and alpha-synuclein immunohistochemistry ((d), (e)). Magnification: x100 (a) and x400 ((b)–(e)).
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