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International Journal of Alzheimer’s Disease
Volume 2010, Article ID 548145, 12 pages
http://dx.doi.org/10.4061/2010/548145
Review Article

cNEUPRO: Novel Biomarkers for Neurodegenerative Diseases

1Laboratory for Molecular Neurobiology, Department of Psychiatry and Psychotherapy, University of Duisburg-Essen, LVR-Klinikum Essen, Virchowstraße 174, 45147 Essen, Germany
2Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 431 80 Mölndal, Sweden
3Inserm U837, 1 Place de Verdun, 59045 Lille, France
4Faculte de Medicine, Université Lille-Nord de France, UDSL, rue Paul Duez, 59800 Lille, France
5CHU, bd. Pr J. Leclerc, 59037 Lille, France
6Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Ylipistonranta 1C, 70211 Kuopio, Finland
7OncoProteomics Laboratory, Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
8Department of Neurology, University of Szeged, P.O. Box 427, 6701 Szeged, Hungary
9Department of Psychiatry and Psychotherapy, University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany
10Functional Proteomics, Medizinisches Proteom-Center, Ruhr-University Bochum, Universitätsstraße 150, 44780 Bochum, Germany
11Medical Proteomics/Bioanalytics, Medizinisches Proteom-Center, Ruhr-University Bochum, Universitätsstraße 150, 44780 Bochum, Germany
12Medical Toxicology Centre, Institute for Ageing and Health, Institute of Neurosciences, University of Newcastle, Wolfson Unit, Claremont Place, Newcastle upon Tyne NE2 4AA, UK
13Department of Neurology, University of Ulm, Steinhövelstraße 1, 89075 Ulm, Germany
14Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, 06156 Perugia, Italy
15Department of Clinical Chemistry, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands

Received 14 April 2010; Accepted 5 July 2010

Academic Editor: Tuula R. M. Pirttila

Copyright © 2010 Philipp Spitzer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

“clinical NEUroPROteomics of neurodegenerative diseases” (cNEUPRO) is a Specific Targeted Research Project (STREP) within the sixth framework program of the European Commission dedicated to the search for novel biomarker candidates for Alzheimer's disease and other neurodegenerative diseases. The ultimate goal of cNEUPRO is to identify one or more valid biomarker(s) in blood and CSF applicable to support the early and differential diagnosis of dementia disorders. The consortium covers all steps required for the discovery of novel biomarker candidates such as acquisition of high quality CSF and blood samples from relevant patient groups and controls, analysis of body fluids by various methods, and finally assay development and assay validation. Here we report the standardized procedures for diagnosis and preanalytical sample-handling within the project, as well as the status of the ongoing research activities and some first results.