cNEUPRO: Novel Biomarkers for Neurodegenerative Diseases

Box 2

Diagnostic standard operating procedure. AD = Alzheimer’s Disease, DLB = Dementia with Lewy-bodies, VaD = Vascular Dementia, FTLD = frontotemporal lobar degeneration, CJD = Creutzfeldt-Jacob Disease, CDR = Clinical Dementia Rating Scale, MMSE = Mini Mental Status Examination. References in the box: [27–32].

Diagnostic standard operating procedure

(i) AD is diagnosed according to the NINCDS-ADRDA criteria [27].

(ii) DLB is diagnosed according to the criteria of McKeith [28].

(iii) VaD is diagnosed according to the NINCDS-AIREN criteria [29].

(iv) FTLD is diagnosed according to the consensus criteria of Neary [30].

(v) CJD is diagnosed according to the WHO criteria (Geneva 1998).

(vi) CDR is used for staging of Dementia [31].

(vii) MMSE is used for grading of dementia [32].

(viii) A follow-up of two years must be retrievable.

(ix) Additional neuropsychological testing is desirable but not mandatory.

(x) A CT or MRI scan must be available.

(xi) The ApoE genotype should be determined.

(xii) CSF should be obtained and the concentration of A${\beta }_{1\text{-}42}$, tau and phospho-tau should be determined.