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International Journal of Alzheimer’s Disease
Volume 2010, Article ID 548145, 12 pages
http://dx.doi.org/10.4061/2010/548145
Review Article

cNEUPRO: Novel Biomarkers for Neurodegenerative Diseases

1Laboratory for Molecular Neurobiology, Department of Psychiatry and Psychotherapy, University of Duisburg-Essen, LVR-Klinikum Essen, Virchowstraße 174, 45147 Essen, Germany
2Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 431 80 Mölndal, Sweden
3Inserm U837, 1 Place de Verdun, 59045 Lille, France
4Faculte de Medicine, Université Lille-Nord de France, UDSL, rue Paul Duez, 59800 Lille, France
5CHU, bd. Pr J. Leclerc, 59037 Lille, France
6Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Ylipistonranta 1C, 70211 Kuopio, Finland
7OncoProteomics Laboratory, Department of Medical Oncology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
8Department of Neurology, University of Szeged, P.O. Box 427, 6701 Szeged, Hungary
9Department of Psychiatry and Psychotherapy, University of Erlangen, Schwabachanlage 6, 91054 Erlangen, Germany
10Functional Proteomics, Medizinisches Proteom-Center, Ruhr-University Bochum, Universitätsstraße 150, 44780 Bochum, Germany
11Medical Proteomics/Bioanalytics, Medizinisches Proteom-Center, Ruhr-University Bochum, Universitätsstraße 150, 44780 Bochum, Germany
12Medical Toxicology Centre, Institute for Ageing and Health, Institute of Neurosciences, University of Newcastle, Wolfson Unit, Claremont Place, Newcastle upon Tyne NE2 4AA, UK
13Department of Neurology, University of Ulm, Steinhövelstraße 1, 89075 Ulm, Germany
14Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, 06156 Perugia, Italy
15Department of Clinical Chemistry, VU University Medical Center, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands

Received 14 April 2010; Accepted 5 July 2010

Academic Editor: Tuula R. M. Pirttila

Copyright © 2010 Philipp Spitzer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. S. Knopman, S. T. DeKosky, J. L. Cummings et al., “Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology,” Neurology, vol. 56, no. 9, pp. 1143–1153, 2001. View at Google Scholar · View at Scopus
  2. R. C. Petersen and S. Negash, “Mild cognitive impairment: an overview,” CNS Spectrums, vol. 13, no. 1, pp. 45–53, 2008. View at Google Scholar · View at Scopus
  3. R. C. Petersen, G. E. Smith, S. C. Waring, R. J. Ivnik, E. G. Tangalos, and E. Kokmen, “Mild cognitive impairment: clinical characterization and outcome,” Archives of Neurology, vol. 56, no. 3, pp. 303–308, 1999. View at Google Scholar · View at Scopus
  4. S. T. DeKosky and K. Marek, “Looking backward to move forward: early detection of neurodegenerative disorders,” Science, vol. 302, no. 5646, pp. 830–834, 2003. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Davies, B. Wolska, C. Hilbich et al., “A4 amyloid protein deposition and the diagnosis of Alzheimer's disease: prevalence in aged brains determined by immunocytochemistry compared with conventional neuropathologic techniques,” Neurology, vol. 38, no. 11, pp. 1688–1693, 1988. View at Google Scholar · View at Scopus
  6. C. R. Jack Jr., V. J. Lowe, S. D. Weigand et al., “Serial PIB and MRI in normal, mild cognitive impairment and Alzheimers disease: implications for sequence of pathological events in Alzheimers disease,” Brain, vol. 132, no. 5, pp. 1355–1365, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. M. Citron, “Strategies for disease modification in Alzheimer's disease,” Nature Reviews Neuroscience, vol. 5, no. 9, pp. 677–685, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. B. Steiner, S. Wolf, and G. Kempermann, “Adult neurogenesis and neurodegenerative disease,” Regenerative Medicine, vol. 1, no. 1, pp. 15–28, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. O. Lindvall and Z. Kokaia, “Stem cells in human neurodegenerative disorders—time for clinical translation?” Journal of Clinical Investigation, vol. 120, no. 1, pp. 29–40, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Blennow, H. Hampel, M. Weiner, and H. Zetterberg, “Cerebrospinal fluid and plasma biomarkers in Alzheimer disease,” Nature Reviews Neurology, vol. 6, no. 3, pp. 131–144, 2010. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Blennow and H. Hampel, “CSF markers for incipient Alzheimer's disease,” Lancet Neurology, vol. 2, no. 10, pp. 605–613, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Lewczuk and J. Wiltfang, “Neurochemical dementia diagnostics: state of the art and research perspectives,” Proteomics, vol. 8, no. 6, pp. 1292–1301, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. C. Brandt, J. C. Bahl, N. H. H. Heegaard, G. Waldemar, and P. Johannsen, “Usability of cerebrospinal fluid biomarkers in a tertiary memory clinic,” Dementia and Geriatric Cognitive Disorders, vol. 25, no. 6, pp. 553–558, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Otto, P. Lewczuk, and J. Wiltfang, “Neurochemical approaches of cerebrospinal fluid diagnostics in neurodegenerative diseases,” Methods, vol. 44, no. 4, pp. 289–298, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. N. Andreasen, L. Minthon, P. Davidsson et al., “Evaluation of CSF-tau and CSF-Aβ42 as diagnostic markers for Alzheimer disease in clinical practice,” Archives of Neurology, vol. 58, no. 3, pp. 373–379, 2001. View at Google Scholar · View at Scopus
  16. K. Blennow, A. Wallin, and O. Hager, “Low frequency of post-lumbar puncture headache in demented patients,” Acta Neurologica Scandinavica, vol. 88, no. 3, pp. 221–223, 1993. View at Google Scholar · View at Scopus
  17. E. R. Peskind, R. Riekse, J. F. Quinn et al., “Safety and acceptability of the research lumbar puncture,” Alzheimer Disease and Associated Disorders, vol. 19, no. 4, pp. 220–225, 2005. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Peskind, A. Nordberg, T. Darreh-Shori, and H. Soininen, “Safety of lumbar puncture procedures in patients with Alzheimer's disease,” Current Alzheimer Research, vol. 6, no. 3, pp. 290–292, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. H. Zetterberg, U. Rüetschi, E. Portelius et al., “Clinical proteomics in neurodegenerative disorders,” Acta Neurologica Scandinavica, vol. 118, no. 1, pp. 1–11, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. F. Song, A. Poljak, G. A. Smythe, and P. Sachdev, “Plasma biomarkers for mild cognitive impairment and Alzheimer's disease,” Brain Research Reviews, vol. 61, no. 2, pp. 69–80, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. M. A. Korolainen, T. A. Nyman, T. Aittokallio, and T. Pirttilä, “An update on clinical proteomics in Alzheimer's research,” Journal of Neurochemistry, vol. 112, no. 6, pp. 1386–1414, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. N. A. Verwey, W. M. van der Flier, K. Blennow et al., “A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease,” Annals of Clinical Biochemistry, vol. 46, no. 3, pp. 235–240, 2009. View at Publisher · View at Google Scholar · View at Scopus
  23. P. Lewczuk, G. Beck, O. Ganslandt et al., “International quality control survey of neurochemical dementia diagnostics,” Neuroscience Letters, vol. 409, no. 1, pp. 1–4, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. N. Mattsson, H. Zetterberg, O. Hansson et al., “CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment,” Journal of the American Medical Association, vol. 302, no. 4, pp. 385–393, 2009. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Petzold, M. D. Chapman, S. Schraen et al., “An unbiased, staged, multicentre, validation strategy for Alzheimer's disease CSF tau levels,” Experimental Neurology, vol. 223, no. 2, pp. 432–438, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. C. E. Teunissen, A. Petzold, J. L. Bennett et al., “A consensus protocol for the standardization of cerebrospinal fluid collection and biobanking,” Neurology, vol. 73, no. 22, pp. 1914–1922, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. G. McKhann, D. Drachman, M. Folstein, R. Katzman, D. Price, and E. M. Stadlan, “Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease,” Neurology, vol. 34, no. 7, pp. 939–944, 1984. View at Google Scholar
  28. I. G. McKeith, D. Galasko, K. Kosaka et al., “Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop,” Neurology, vol. 47, no. 5, pp. 1113–1124, 1996. View at Google Scholar · View at Scopus
  29. G. C. Roman, T. K. Tatemichi, T. Erkinjuntti et al., “Vascular dementia: diagnostic criteria for research studies: report of the NINDS-AIREN International Workshop,” Neurology, vol. 43, no. 2, pp. 250–260, 1993. View at Google Scholar · View at Scopus
  30. D. Neary, J. S. Snowden, L. Gustafson et al., “Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria,” Neurology, vol. 51, no. 6, pp. 1546–1554, 1998. View at Google Scholar · View at Scopus
  31. J. C. Morris, “The Clinical Dementia Rating (CDR): current version and scoring rules,” Neurology, vol. 43, no. 11, pp. 2412–2414, 1993. View at Google Scholar · View at Scopus
  32. M. F. Folstein, S. E. Folstein, and P. R. McHugh, ““Mini mental state”. A practical method for grading the cognitive state of patients for the clinician,” Journal of Psychiatric Research, vol. 12, no. 3, pp. 189–198, 1975. View at Publisher · View at Google Scholar · View at Scopus
  33. S. Schraen-Maschke, N. Sergeant, C.-M. Dhaenens et al., “Tau as a biomarker of neurodegenerative diseases,” Biomarkers in Medicine, vol. 2, no. 4, pp. 363–384, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. V. Welge, O. Fiege, P. Lewczuk et al., “Combined CSF tau, p-tau181 and amyloid-β 38/40/42 for diagnosing Alzheimer's disease,” Journal of Neural Transmission, vol. 116, no. 2, pp. 203–212, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Bibl, B. Mollenhauer, H. Esselmann et al., “Cerebrospinal fluid neurochemical phenotypes in vascular dementias: original data and mini-review,” Dementia and Geriatric Cognitive Disorders, vol. 25, no. 3, pp. 256–265, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Olsson, K. Höglund, M. Sjögren et al., “Measurement of α- and β-secretase cleaved amyloid precursor protein in cerebrospinal fluid from Alzheimer patients,” Experimental Neurology, vol. 183, no. 1, pp. 74–80, 2003. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Sjögren, P. Davidsson, J. Gottfries et al., “The cerebrospinal fluid levels of tau, growth-associated protein-43 and soluble amyloid precursor protein correlate in Alzheimer's disease, reflecting a common pathophysiological process,” Dementia and Geriatric Cognitive Disorders, vol. 12, no. 4, pp. 257–264, 2001. View at Publisher · View at Google Scholar · View at Scopus
  38. A. Post, N. Ackl, M. Rücker et al., “Toward a reliable distinction between patients with mild cognitive impairment and Alzheimer-type dementia versus major depression,” Biological Psychiatry, vol. 59, no. 9, pp. 858–862, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. K. Sennvik, J. Fastbom, M. Blomberg, L.-O. Wahlund, B. Winblad, and E. Benedikz, “Levels of α- and β-secretase cleaved amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients,” Neuroscience Letters, vol. 278, no. 3, pp. 169–172, 2000. View at Publisher · View at Google Scholar · View at Scopus
  40. W. E. Van Nostrand, S. L. Wagner, W. R. Shankle et al., “Decreased levels of soluble amyloid β-protein precursor in cerebrospinal fluid of live Alzheimer disease patients,” Proceedings of the National Academy of Sciences of the United States of America, vol. 89, no. 7, pp. 2551–2555, 1992. View at Google Scholar · View at Scopus
  41. P. Lewczuk, H. Kamrowski-Kruck, O. Peters et al., “Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study,” Molecular Psychiatry, vol. 15, no. 2, pp. 138–145, 2010. View at Publisher · View at Google Scholar · View at Scopus
  42. E. Portelius, G. Brinkmalm, A. Tran et al., “Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid,” Experimental Neurology, vol. 223, no. 2, pp. 351–358, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. E. Portelius, G. Brinkmalm, A. J. Tran, H. Zetterberg, A. Westman-Brinkmalm, and K. Blennow, “Identification of novel APP/Aβ isoforms in human cerebrospinal fluid,” Neurodegenerative Diseases, vol. 6, no. 3, pp. 87–94, 2009. View at Publisher · View at Google Scholar · View at Scopus
  44. H.-W. Klafki, P. Lewczuk, H. Kamrowski-Kruck et al., “Measurement of ERK 1/2 in CSF from patients with neuropsychiatric disorders and evidence for the presence of the activated form,” Journal of Alzheimer's Disease, vol. 18, no. 3, pp. 613–622, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. R. Fukuyama, T. Izumoto, and S. Fushiki, “The cerebrospinal fluid level of glial fibrillary acidic protein is increased in cerebrospinal fluid from Alzheimer's disease patients and correlates with severity of dementia,” European Neurology, vol. 46, no. 1, pp. 35–38, 2001. View at Publisher · View at Google Scholar · View at Scopus
  46. S. Jesse, P. Steinacker, L. Cepek et al., “Glial fibrillary acidic protein and protein S-100B: different concentration pattern of glial proteins in cerebrospinal fluid of patients with Alzheimer's disease and Creutzfeldt-Jakob disease,” Journal of Alzheimer's Disease, vol. 17, no. 3, pp. 541–551, 2009. View at Publisher · View at Google Scholar · View at Scopus
  47. M. C. Polidori, H. R. Griffiths, E. Mariani, and P. Mecocci, “Hallmarks of protein oxidative damage in neurodegenerative diseases: focus on Alzheimer's disease,” Amino Acids, vol. 32, no. 4, pp. 553–559, 2007. View at Publisher · View at Google Scholar · View at Scopus
  48. M. A. Korolainen and T. Pirttilä, “Cerebrospinal fluid, serum and plasma protein oxidation in Alzheimer's disease,” Acta Neurologica Scandinavica, vol. 119, no. 1, pp. 32–38, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. J. N. Keller, F. A. Schmitt, S. W. Scheff et al., “Evidence of increased oxidative damage in subjects with mild cognitive impairment,” Neurology, vol. 64, no. 7, pp. 1152–1156, 2005. View at Google Scholar · View at Scopus
  50. N. Ahmed, U. Ahmed, P. J. Thornalley, K. Hager, G. Fleischer, and G. Münch, “Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairment,” Journal of Neurochemistry, vol. 92, no. 2, pp. 255–263, 2005. View at Publisher · View at Google Scholar · View at Scopus
  51. M. A. Korolainen, T. A. Nyman, P. Nyyssönen, E. S. Hartikainen, and T. Pirttilä, “Multiplexed proteomic analysis of oxidation and concentrations of cerebrospinal fluid proteins in Alzheimer disease,” Clinical Chemistry, vol. 53, no. 4, pp. 657–665, 2007. View at Publisher · View at Google Scholar · View at Scopus
  52. H. Tohgi, T. Abe, K. Yamazaki, T. Murata, E. Ishizaki, and C. Isobe, “Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease,” Neuroscience Letters, vol. 269, no. 1, pp. 52–54, 1999. View at Publisher · View at Google Scholar · View at Scopus
  53. H. Ryberg, A.-S. Söderling, P. Davidsson, K. Blennow, K. Caidahl, and L. I. Persson, “Cerebrospinal fluid levels of free 3-nitrotyrosine are not elevated in the majority of patients with amyotrophic lateral sclerosis or Alzheimer's disease,” Neurochemistry International, vol. 45, no. 1, pp. 57–62, 2004. View at Publisher · View at Google Scholar · View at Scopus
  54. P. Brechlin, O. Jahn, P. Steinacker et al., “Cerebrospinal fluid-optimized two-dimensional difference gel electrophoresis (2-D DIGE) facilitates the differential diagnosis of Creutzfeldt-Jakob disease,” Proteomics, vol. 8, no. 20, pp. 4357–4366, 2008. View at Publisher · View at Google Scholar · View at Scopus
  55. P. Steinacker, W. Rist, M. Swiatek-de-Lange et al., “Ubiquitin as potential cerebrospinal fluid marker of Creutzfeldt-Jakob disease,” Proteomics, vol. 10, no. 1, pp. 81–89, 2010. View at Publisher · View at Google Scholar · View at Scopus
  56. C. Piubelli, M. Fiorini, G. Zanusso et al., “Searching for markers of Creutzfeldt-Jakob disease in cerebrospinal fluid by two-dimensional mapping,” Proteomics, vol. 6, pp. S256–S261, 2006. View at Google Scholar · View at Scopus
  57. P. Davidsson, A. Westman-Brinkmalm, C. L. Nilsson et al., “Proteome analysis of cerebrospinal fluid proteins in Alzheimer patients,” NeuroReport, vol. 13, no. 5, pp. 611–615, 2002. View at Google Scholar · View at Scopus
  58. K. Iqbal and I. Grundke-Iqbal, “Elevated levels of τ and ubiquitin in brain and cerebrospinal fluid in Alzheimer's disease,” International Psychogeriatrics, vol. 9, no. 1, pp. 289–296, 1997. View at Publisher · View at Google Scholar · View at Scopus
  59. T. Kudo, K. Iqbal, R. Ravid, D. F. Swaab, and I. Grundke-Iqbal, “Alzheimer disease: correlation of cerebro-spinal fluid and brain ubiquitin levels,” Brain Research, vol. 639, no. 1, pp. 1–7, 1994. View at Publisher · View at Google Scholar · View at Scopus
  60. K. Blennow, P. Davidsson, A. Wallin, C.-G. Gottfries, and L. Svennerholm, “Ubiquitin in cerebrospinal fluid in Alzheimer's disease and vascular dementia,” International Psychogeriatrics, vol. 6, no. 1, pp. 13–22, 1994. View at Publisher · View at Google Scholar · View at Scopus
  61. M. Otto, J. Wiltfang, L. Cepek et al., “Tau protein and 14-3-3 protein in the differential diagnosis of Creutzfeldt-Jakob disease,” Neurology, vol. 58, no. 2, pp. 192–197, 2002. View at Google Scholar · View at Scopus
  62. M. Otto, H. Stein, A. Szudra et al., “S-100 protein concentration in the cerebrospinal fluid of patients with Creutzfeldt-Jakob disease,” Journal of Neurology, vol. 244, no. 9, pp. 566–570, 1997. View at Publisher · View at Google Scholar · View at Scopus
  63. M. Otto, J. Wiltfang, E. Schütz et al., “Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum: prospective case-control study,” British Medical Journal, vol. 316, no. 7131, pp. 577–582, 1998. View at Google Scholar · View at Scopus
  64. A. Ladogana, P. Sanchez-Juan, E. Mitrová et al., “Cerebrospinal fluid biomarkers in human genetic transmissible spongiform encephalopathies,” Journal of Neurology, vol. 256, no. 10, pp. 1620–1628, 2009. View at Publisher · View at Google Scholar · View at Scopus
  65. E. R. Peskind, W. S. T. Griffin, K. T. Akama, M. A. Raskind, and L. J. Van Eldik, “Cerebrospinal fluid S100B is elevated in the earlier stages of Alzheimer's disease,” Neurochemistry International, vol. 39, no. 5-6, pp. 409–413, 2001. View at Publisher · View at Google Scholar · View at Scopus
  66. M. L. Chaves, A. L. Camozzato, E. D. Ferreira et al., “Serum levels of S100B and NSE proteins in Alzheimer's disease patients,” Journal of Neuroinflammation, vol. 7, article 6, 2010. View at Publisher · View at Google Scholar · View at Scopus
  67. P. Steinacker, C. Hendrich, A. D. Sperfeld et al., “TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis,” Archives of Neurology, vol. 65, no. 11, pp. 1481–1487, 2008. View at Publisher · View at Google Scholar · View at Scopus
  68. P. Steinacker, C. Hendrich, A.-D. Sperfeld et al., “Concentrations of beta-amyloid precursor protein processing products in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration,” Journal of Neural Transmission, vol. 116, no. 9, pp. 1169–1178, 2009. View at Publisher · View at Google Scholar · View at Scopus
  69. M. Mishra, T. Paunesku, G. E. Woloschak et al., “Gene expression analysis of frontotemporal lobar degeneration of the motor neuron disease type with ubiquitinated inclusions,” Acta Neuropathologica, vol. 114, no. 1, pp. 81–94, 2007. View at Publisher · View at Google Scholar · View at Scopus
  70. M. Bibl, B. Mollenhauer, S. Wolf et al., “Reduced CSF carboxyterminally truncated Aβ peptides in frontotemporal lobe degenerations,” Journal of Neural Transmission, vol. 114, no. 5, pp. 621–628, 2007. View at Publisher · View at Google Scholar · View at Scopus
  71. M. Bibl, B. Mollenhauer, P. Lewczuk et al., “Validation of amyloid-β peptides in CSF diagnosis of neurodegenerative dementias,” Molecular Psychiatry, vol. 12, no. 7, pp. 671–680, 2007. View at Publisher · View at Google Scholar · View at Scopus
  72. M. Riemenschneider, S. Wagenpfeil, J. Diehl et al., “Tau and Aβ42 protein in CSF of patients with frontotemporal degeneration,” Neurology, vol. 58, no. 11, pp. 1622–1628, 2002. View at Google Scholar · View at Scopus
  73. M. Sjögren, P. Davidsson, A. Wallin et al., “Decreased CSF-β-amyloid 42 in Alzheimer's disease and amyotrophic lateral sclerosis may reflect mismetabolism of β-amyloid induced by disparate mechanisms,” Dementia and Geriatric Cognitive Disorders, vol. 13, no. 2, pp. 112–118, 2002. View at Publisher · View at Google Scholar · View at Scopus
  74. H. Bian, J. C. Van Swieten, S. Leight et al., “CSF biomarkers in frontotemporal lobar degeneration with known pathology,” Neurology, vol. 70, no. 19, pp. 1827–1835, 2008. View at Publisher · View at Google Scholar · View at Scopus
  75. Y. A. L. Pijnenburg, J. C. Janssen, N. S. M. Schoonenboom et al., “CSF neurofilaments in frontotemporal dementia compared with early onset Alzheimer's disease and controls,” Dementia and Geriatric Cognitive Disorders, vol. 23, no. 4, pp. 225–230, 2007. View at Publisher · View at Google Scholar · View at Scopus
  76. L. Parnetti, P. Tiraboschi, A. Lanari et al., “Cerebrospinal fluid biomarkers in Parkinson's disease with dementia and dementia with Lewy bodies,” Biological Psychiatry, vol. 64, no. 10, pp. 850–855, 2008. View at Publisher · View at Google Scholar · View at Scopus
  77. S. Jesse, P. Steinacker, S. Lehnert, F. Gillardon, B. Hengerer, and M. Otto, “Neurochemical approaches in the laboratory diagnosis of Parkinson and Parkinson dementia syndromes: a review,” CNS Neuroscience and Therapeutics, vol. 15, no. 2, pp. 157–182, 2009. View at Publisher · View at Google Scholar · View at Scopus
  78. C. Balducci, L. Pierguidi, E. Persichetti et al., “Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease,” Movement Disorders, vol. 22, no. 10, pp. 1481–1484, 2007. View at Publisher · View at Google Scholar · View at Scopus
  79. L. Parnetti, C. Balducci, L. Pierguidi et al., “Cerebrospinal fluid β-glucocerebrosidase activity is reduced in Dementia with Lewy Bodies,” Neurobiology of Disease, vol. 34, no. 3, pp. 484–486, 2009. View at Publisher · View at Google Scholar · View at Scopus
  80. P. Lewczuk, J. Kornhuber, E. Vanmechelen et al., “Amyloid β peptides in plasma in early diagnosis of Alzheimer's disease: a multicenter study with multiplexing,” Experimental Neurology, vol. 223, no. 2, pp. 366–370, 2010. View at Publisher · View at Google Scholar · View at Scopus
  81. J.-C. Lambert, S. Schraen-Maschke, F. Richard et al., “Association of plasma amyloid β with risk of dementia: the prospective Three-City Study,” Neurology, vol. 73, no. 11, pp. 847–853, 2009. View at Publisher · View at Google Scholar · View at Scopus
  82. M. C. Irizarry, “Biomarkers of Alzheimer disease in plasma,” NeuroRx, vol. 1, no. 2, pp. 226–234, 2004. View at Publisher · View at Google Scholar · View at Scopus
  83. P. Schneider, H. Hampel, and K. Buerger, “Biological marker candidates of alzheimer's disease in blood, plasma, and serum,” CNS Neuroscience and Therapeutics, vol. 15, no. 4, pp. 358–374, 2009. View at Publisher · View at Google Scholar · View at Scopus
  84. O. Hansson, H. Zetterberg, E. Vanmechelen et al., “Evaluation of plasma Aβ40 and Aβ42 as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment,” Neurobiology of Aging, vol. 31, no. 3, pp. 357–367, 2010. View at Publisher · View at Google Scholar · View at Scopus
  85. M. Bibl, H. Esselmann, B. Mollenhauer et al., “Blood-based neurochemical diagnosis of vascular dementia: a pilot study,” Journal of Neurochemistry, vol. 103, no. 2, pp. 467–474, 2007. View at Publisher · View at Google Scholar · View at Scopus
  86. J. M. Maler, H.-W. Klafki, S. Paul et al., “Urea-based two-dimensional electrophoresis of beta-amyloid peptides in human plasma: evidence for novel Aβ species,” Proteomics, vol. 7, no. 20, pp. 3815–3820, 2007. View at Publisher · View at Google Scholar · View at Scopus
  87. J. M. Maler, P. Spitzer, H.-W. Klafki et al., “Adherence-dependent shifts in the patterns of β-amyloid peptides secreted by human mononuclear phagocytes,” Brain, Behavior, and Immunity, vol. 22, no. 7, pp. 1044–1048, 2008. View at Publisher · View at Google Scholar · View at Scopus
  88. J. M. Maler, P. Spitzer, H.-W. Klafki et al., “Distinct fractional Aβ release patterns in human mononuclear phagocytes,” Journal of Neuroimmunology, vol. 206, no. 1-2, pp. 1–4, 2009. View at Publisher · View at Google Scholar · View at Scopus
  89. S. Roche, A. Gabelle, and S. Lehmann, “Clinical proteomics of the cerebrospinal fluid: towards the discovery of new biomarkers,” Proteomics—Clinical Applications, vol. 2, no. 3, pp. 428–436, 2008. View at Publisher · View at Google Scholar · View at Scopus
  90. S. Roche, L. Tiers, M. Provansal et al., “Depletion of one, six, twelve or twenty major blood proteins before proteomic analysis: the more the better?” Journal of Proteomics, vol. 72, no. 6, pp. 945–951, 2009. View at Publisher · View at Google Scholar · View at Scopus
  91. K. B. Walhovd, A. M. Fjell, J. Brewer et al., “Combining MR imaging, positron-emission tomography, and CSF biomarkers in the diagnosis and prognosis of Alzheimer disease,” American Journal of Neuroradiology, vol. 31, no. 2, pp. 347–354, 2010. View at Publisher · View at Google Scholar · View at Scopus