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International Journal of Alzheimer’s Disease
Volume 2010 (2010), Article ID 673581, 7 pages
http://dx.doi.org/10.4061/2010/673581
Research Article

Predictors of the Progression of Dementia Severity in Brazilian Patients with Alzheimer's Disease and Vascular Dementia

1Dementia Outpatient Clinic and Behavioral Sciences Program, Neurology Service and Medical Sciences Post-Graduation Course, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul School of Medicine, Porto Alegre 90035-903, Brazil
2Dementia Outpatient Clinic and Behavioral Sciences Program, Neurology Service, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul School of Medicine, Porto Alegre 90035-903, Brazil
3Layton Aging and Alzheimer's Disease Center, Oregon Health & Science University, Portland, OR 97239, USA

Received 13 September 2009; Revised 15 December 2009; Accepted 17 January 2010

Academic Editor: Leonardo Pantoni

Copyright © 2010 Márcia L. Chaves et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Introduction. This study evaluates the progression of dementia and identifies prognostic risk factors for dementia. Methods. A group of 80 Brazilian community residents with dementia (34 with Alzheimer's disease and 46 with vascular dementia) was assessed over the course of 2 years. Data were analyzed with Cox regression survival analysis. Results. The data showed that education predicted cognitive decline ( ; ) when analyzed without controlling for vascular risk factors. After the inclusion of vascular risk factors, education ( ; ) and hypertension were predictive for cognitive decline ( ; ), and Alzheimer's disease diagnosis was borderline predictive ( ). Conclusion. Vascular risk factors interacted with the diagnosis of vascular dementia. Education was a strong predictor of decline.