International Journal of Alzheimer’s Disease / 2010 / Article / Tab 1

Review Article

Neuron Loss in Transgenic Mouse Models of Alzheimer's Disease

Table 1

Overview of transgenic AD mouse models in which neuronal loss and/or intraneuronal A accumulation has been reported. In addition, information on the transgene, extracellular plaque onset, and intraneuronal A accumulation are given. (n.d.: not determined).

Transgenic mouse modelMutation APPMutation PS1PromoterPlaque onsetIntraneur. A Neuron lossSynaptic dysfunctionReference

NF-L-A NF-L (A )n.d. n.d.[24]
APP23SwedishThy1 (APP)6 mn.d.14–18 m [25]
x PS1M146LSwedish, LondonM146LThy1 (APP) HMG-CoA (PS1)3 m 17 m [16]
/ PS1KISwedish, LondonM233T, L235PThy1 (APP) PS1 knockin2 m 6 m [18]
5XFADSwedish, Florida, LondonM146L, L286VThy1 (APP, PS1)2 m 9 m [28]
TBA2Thy1 (AbpE3-42)2 m 2 mn.d.[42]
JapanesePrp (APP) 24 m [14]
3xTgSwedishM146VThy1 (APP, Tau) PS1 knockin6 m n.d. [20]
APP/tauSwedishPrion Protein (APP) Thy1 (Tau)9 mn.d.9 mn.d.[19]
TauPS2APPSwedishN141I (PS2)Thy1 (APP, PS2, Tau)4 mn.d.n.d.[46]

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