Neuron Loss in Transgenic Mouse Models of Alzheimer's Disease

Table 1

Overview of transgenic AD mouse models in which neuronal loss and/or intraneuronal A𝛽 accumulation has been reported. In addition, information on the transgene, extracellular plaque onset, and intraneuronal A𝛽 accumulation are given. (n.d.: not determined).

Transgenic mouse model	Mutation APP	Mutation PS1	Promoter	Plaque onset	Intraneur. A𝛽	Neuron loss	Synaptic dysfunction	Reference
NF-L-A𝛽	—	—	NF-L (A𝛽)	n.d.	√	√	n.d.	[24]
APP23	Swedish	—	Thy1 (APP)	6 m	n.d.	14–18 m	—	[25]
APP751SLx PS1M146L	Swedish, London	M146L	Thy1 (APP) HMG-CoA (PS1)	3 m	√	17 m	√	[16]
APP751SL/ PS1KI	Swedish, London	M233T, L235P	Thy1 (APP) PS1 knockin	2 m	√	6 m	√	[18]
5XFAD	Swedish, Florida, London	M146L, L286V	Thy1 (APP, PS1)	2 m	√	9 m	√	[28]
TBA2	—	—	Thy1 (AbpE3-42)	2 m	√	2 m	n.d.	[42]
APPE693Δ	Japanese	—	Prp (APP)	—	√	24 m	√	[14]
3xTg	Swedish	M146V	Thy1 (APP, Tau) PS1 knockin	6 m	√	n.d.	√	[20]
APP/tau	Swedish	—	Prion Protein (APP) Thy1 (Tau)	9 m	n.d.	9 m	n.d.	[19]
TauPS2APP	Swedish	N141I (PS2)	Thy1 (APP, PS2, Tau)	4 m	n.d.	—	n.d.	[46]