Choline Modulation of the Aβ P1-40 Channel Reconstituted into a Model Lipid Membrane
Figure 1
AβP1-40 channel activity in OxCh PLM in the absence and in the presence of choline. Representative AβP1-40 channel in the absence (a), in the presence of choline on the cis (b), or on the trans (c) side of the medium facing an OxCh PLM at an applied voltage of ±60 mV. Each trace represents a fragment of the recording of the activity obtained in individual experiments. Note the increased activity of the channel and the frequent multiple levels of conductance, especially at positive applied voltages, when choline is present. Experimental conditions KCl 50 mM, AβP1-40 5 ×10−8 M were present to the cis side of the membrane, choline 5 ×10−11 M was added on the cis or trans side of the membrane.
