Choline Modulation of the Aβ P1-40 Channel Reconstituted into a Model Lipid Membrane

Table 1

The channel lifetime of AβP1-40 in OxCh PLM. The fitted lifetime (see text) of AβP1-40 in the absence (a) and in the presence of choline (5 ×10⁻¹¹ M) added on the cis/trans side of the medium facing the OxCh PLM (b/c, resp.). The minimum and maximum number of channels considered (𝑁) out of a total number of channels considered (𝑁_𝑡) was: (a) 125<𝑁<503, 𝑁_𝑡=1214; (b) 95<𝑁<217, 𝑁_𝑡=834; (c) 102<𝑁<186, 𝑁_𝑡=857. 𝐹-test, ^∗𝑃=.102.

Vs (mV)	a		b		c
	𝜏1 (s)	𝜏2 (s)	𝜏1 (s)	𝜏2 (s)	𝜏1 (s)	𝜏2 (s)
60	2.07		1.53	8.34	1.45	7.76
40	3.56		1.88	19.61	1.58	8.46
20	1.12		1.29	20.01	1.17	6.49
−20	1.05^∗		2.23	32.26	0.25	5.03
−40	1.17	4.96	3.69		0.15	3.94
−60	1.33	8.99	2.23		2.54