|
| Mouse model | Exposure | Duration exposure | Age at start exposure | Effects on brain | Effects on behaviour | Reference |
|
| APP-YAC | Cortical contusion impact (3-mm diameter impounder onto the left parietal cortex, 100 ms; velocity () = 4.8−5.2 m/s; depth = 1 mm) | — | 10–16 months | No difference | No difference in MWM | [149] |
|
| PDAPP | Cortical impact brain injury (3-mm diameter impounder onto the left parietal cortex, 100 ms; = 4.8−5.2 m/s; depth = 1 mm) | — | 4 months | Increased hippocampal neuronal death | MWM memory impairment in transgenic as compared to controls | [150] |
|
| PDAPP | Controlled cortical impact (3-mm diameter impounder onto the left parietal cortex, 100 ms; = 4.8−5.2 m/s; depth = 1 mm) | — | 6 months | Hippocampal atrophyDecrease the hippocampus and cingulate cortex 3 months after TBI | Not measured | [156] |
|
| PDAPP | Controlled cortical impact (3-mm diameter impounder onto the left parietal cortex, 100 ms; = 4.8−5.2 m/s; depth = 1 mm) | — | 24 months | Increased hippocampal neuronal loss and gliosis Regression of in the hippocampus | Not measured | [157] |
|
| APPswe | Controlled cortical impact (3-mm diameter impounder onto the left parietal cortex, 47 ms; = 5.82 m/s; depth = 1.2 mm, driving pressure 73 psi) | — | 3 months | 2 increase in 40 and 42
Reduced CA3 ynaptophysin immunoreactivity | MWM performance deficit | [152] |
|
| Tg2576 | Controlled cortical impact (mild to moderate, 2-mm diameter impounder onto the right cortex, = 3.3 m/s; depth = 1 mm) | — | 22 months | Gene expression differences in inflammation, immune response and cell death | Not measured | [153] |
|
| Tg2576 | Controlled cortical impact (3-mm diameter impounder onto the left parietal cortex, 100 ms; = 4.8−5.2 m/s; depth = 1 mm) | Repetitive (2) | 9 months | Increased hippocampal amyloid deposition | MWM cognitive dysfunction | [154] |
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