Ablation of the Locus Coeruleus Increases Oxidative Stress in Tg-2576 Transgenic but Not Wild-Type Mice

Figure 3

Glutathione metabolism. Glutathione metabolism and gamma-glutamyl-dipeptide formation are altered in the brains of the Tg2576_DSP4 group. For each metabolite, the distribution of values within each of the four cohorts is represented as a Whisker plot, with the relative normalized intensity as the abscissa. Mean values represented by the black arrowheads, median values by blue arrowheads. Detailed statistical comparisons of oxidized glutathione, reduced glutathione, and  𝛾-glutamine-leucine are given in Table 1. Glutamic acid was omitted from the table even though the 𝑃-value for the comparison of ablated transgenics to ablated wild-types was  .0109, the 𝑄-value exceeded our threshold at a value of 0.154.