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Figure 5: Carbohydrate metabolism. Box plots demonstrating selective depressions in the brains of glucose-6-phosphate (an early intermediary of anaerobic glycolysis as well as the pentose monophosphate shunt), lactate the end product of anaerobic glycolysis, and D-arabitol, a polyol with antioxidant properties which is thought to be a product of the pentose phosphate pathway. For each metabolite, the distribution of values within each of the four cohorts is represented as a Whisker plot, with the relative normalized intensity as the abscissa. Mean values represented by the black arrowheads, median values by blue arrowheads. Detailed statistical comparisons of each of the pictured metabolites in the four cohorts are given in Table 1.