Research Article

Chronic Cerebral Ischaemia Forms New Cholinergic Mechanisms of Learning and Memory

Figure 6

Influence of the agonist of subtype of nAChR RJR and the antagonist of non- subtype of nAChR mecamilamine (MEC) on learning 2s2–4 (top row of figures) and 3s2–4 (bottom row of figures) in rats in the Morris water maze in the spatial contextual and the spatial cued models under control and 2VO conditions. The learning performance is presented as latency time (sec). Seline, control rat’s groups ( for learning as 2s2–4 and 3s2–4 in the contextual model; for the ones in the cued model); RJR, MEC, groups of rats with RJR or MEC administered under the normal conditions ( for both groups for learning as 2s2–4 and 3s2–4 in the contextual model; , 11 for learning 2s2–4 in RJR, MEC groups, respectively, and , 11 for learning 3s2–4 in ones in the cued model); 2VO + seline, the 2VO rat’s group ( for learning as 2s2–4 and 3s2–4 in the contextual model; for the ones in the cued model); 2VO + RJR, 2VO + MEC, groups of rats with RJR or MEC administered under the 2VO conditions (resp., , 10 for learning as 2s2–4 and 3s2–4 in the contextual model; , 9 for the ones in the cued model). *, **, significant differences from control rat’s group ( and , resp.); #,# #, significant differences between RJR and MEC or 2VO + RJR and 2VO + MEC rat’s groups ( and , resp.); &&, significant differences between 2VO and 2VO + MEC rat’s groups ( ) by the Fisher’s Exact test.
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