Research Article

Chronic Cerebral Ischaemia Forms New Cholinergic Mechanisms of Learning and Memory

Table 2

-criterion values by the Pearson’s test between behavioural performance and ChAT activity in rats in the Morris water maze in the spatial contextual (Contextual) and spatial cued (Cued) behavioural models in the control (Sham) and ischaemic (2VO) conditions. 1s2/1s1, 1s3-4/1s2–4, 2s2–4, 3s2–4, 2s1, 3s1, the abbreviations of the forms of cognition are the same as in Figure 1; sm and Sp, respectively subfractions of the synaptic membranes and the synaptoplasm of the cortical light (CL) and heavy synaptosomes (CH) and hippocampal light (HL) and eavy synaptosomes (HH) as in Table 1. The signs of correlations were placed as plus and minus for the purpose of direct reflection of correlations between performance of the cognitive functions and ChAT activity in the subfractions. The positive (plus) sign of value reflects the positive influence on cognitive function of the corresponding synaptic population and the negative (minus) sign of value reflects accordingly the negative influence on the function of the corresponding synaptic population. In the control and 2VO spatial contextual biochemical rat subgroups per group; in the control and 2VO spatial cued biochemical rat subgroups per group. *,**, ***, significant -criterion values of correlations between behavioural performance and ChAT activity ( , , , resp.) by the Pearson’s test. Significant -criterion values were marked in bold values.

ContextualCued
sham1s21s3-42s2–43s2–42s13s11s11s2–42s2–43s2–42s13s1

CLSm+0.487−0.359+0.994***+1***+0.295+0.575+0.4051***−0.196+0.409−0.234−0.808
Sp+0.961*−0.242−0.729−0.396+0.6891***+0.673+0.515+0.425−0.429+0.249+0.966*
CHsm+0.776−0.268−0.441−0.246+0.980*−0.596+0.6170.982*−0.617−0.023−0.501−0.503
Sp+0.388−0.343+0.145+0.145+0.965*−0.219−0.041−0.052+0.958*+0.997**+0.978*−0.369
HLsm+0.106+0.997***−0.292−0.2630.967*+0.207−0.187+0.667+0.759+0.475+0.993**+0.340
Sp−0.6140.988*+0.645+0.591+0.460+0.317−0.276−0.249+0.974*+1***+0.658_0.640
HHsm0.967*−0.288+0.985*+0.998***−0.120+0.979*−0.413+0.971*+0.684+0.202+0.730+0.501
Sp0.992***+0.079+0.601+0.549−0.720+0.993***+0.644−0.565+0.127+0.689+0.466−0.448

2VO1s21s3-42s2–43s2–42s13s11s11s2–42s2–43s2–42s13s1

CLsm−0.464−0.270+0.548+0.006+0.242+0.450+0.400+0.3210.981*+0.986*−0.677−0.139
Sp−0.656−0.153−0.326−0.797+0.198−0.510+0.577+0.0470.954*+0.998**−0.752−0.377
CHsm+0.082+0.477−0.403−0.750−0.482−0.110−0.307+0.955*0.995**+0.403−0.784+0.553
Sp−0.328−0.004−0.231−0.350−0.022+0.304+0.356+0.3730.982*+0.978*−0.655−0.095
HLsm−0.162−0.518−0.302−0.387+0.426+0.375+0.160+0.419−0.782+0.637−0.843+0.133
Sp−0.7650.928*+0.169−0.1190.908*+0.145+0.264+0.319−0.756+0.691−0.727+0.027
HHsm−0.709−0.434−0.4540.905*+0.448−0.411+0.711−0.346−0.559+0.779−0.634−0.606
Sp−0.497−0.408−0.382−0.753+0.372−0.027−0.604+0.780−0.632+0.050−0.558+0.680