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International Journal of Alzheimer’s Disease
Volume 2011, Article ID 127984, 17 pages
Review Article

Aβ Internalization by Neurons and Glia

Department of Pharmacology, University of Alberta, Edmonton, AB, Canada T6G 2H7

Received 23 October 2010; Accepted 23 December 2010

Academic Editor: Anne Eckert

Copyright © 2011 Amany Mohamed and Elena Posse de Chaves. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


In the brain, the amyloid β peptide (Aβ) exists extracellularly and inside neurons. The intracellular accumulation of Aβ in Alzheimer's disease brain has been questioned for a long time. However, there is now sufficient strong evidence indicating that accumulation of Aβ inside neurons plays an important role in the pathogenesis of Alzheimer's disease. Intraneuronal Aβ originates from intracellular cleavage of APP and from Aβ internalization from the extracellular milieu. We discuss here the different molecular mechanisms that are responsible for Aβ internalization in neurons and the links between Aβ internalization and neuronal dysfunction and death. A brief description of Aβ uptake by glia is also presented.