Review Article

Link between Aluminum and the Pathogenesis of Alzheimer's Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses

Table 2

Al-induced conformational changes of various proteins.

ProteinsReferences

Disease-related proteins
Alzheimer’s disease
  A P (1-40)[64, 131134]
   DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
  A P (1-42):[135, 136]
   DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
  A P (25-35):[137]
   GSNKGAIIGLMV
  APP[138]
  Tau or hyperphosphorylated tau (PHF-tau)[32, 57, 139]
Perkinson’s disease and other diseases with Lewy body
   -synuclein (NACP)[140, 141]
Type 2 diabetes mellitus
  Amylin:[142]
   KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY
Familial British dementia
  ABri:[143]
   ASNCPAIRHPGNKPAVGTLICSRTVKKNIIGGN
Spinocerebellar ataxia
  Ataxin 3[144]
Dialysis-related arthropathy
-microglobulin[145]