Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein
Figure 1
Effects of AβP on temporal changes of [Ca2+]i. (a) Pseudocolor images of [Ca2+]i during exposure to AβP(1–40) in GT1-7 cells. A solution of AβP(1–40) (10 μM) was applied onto fura-2-loaded GT1-7 cells. Temporal changes of fluorescence intensities corresponding to increases in [Ca2+]i were analyzed. (A) 1 min before exposure to AβP(1–40); (B) 20 sec after exposure; (C) 5 min after exposure. (b) Temporal changes of randomly chosen 50 GT1-7 cells in the same field of view before and after the exposure to AβP(1–40) are depicted. The arrow indicates the time of peptide addition.
