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International Journal of Alzheimer’s Disease
Volume 2011, Article ID 312341, 7 pages
http://dx.doi.org/10.4061/2011/312341
Research Article

A Novel Study and Meta-Analysis of the Genetic Variation of the Serotonin Transporter Promoter in the Italian Population Do Not Support a Large Effect on Alzheimer's Disease Risk

1Department of Neuroscience, Mario Negri Institute for Pharmacological Research, 20156 Milan, Italy
2Golgi Cenci Research Center, Abbiategrasso, 20081 Milan, Italy
3Department of Neurological Sciences, University of Milan, IRCCS Fondazione Cà Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy
4Neurology Unit, Luigi Sacco Hospital, University of Milan, 20157 Milan, Italy

Received 23 November 2010; Revised 31 January 2011; Accepted 27 March 2011

Academic Editor: Lars Bertram

Copyright © 2011 Letizia Polito et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Ravaglia, P. Forti, F. Maioli et al., “Incidence and etiology of dementia in a large elderly Italian population,” Neurology, vol. 64, no. 9, pp. 1525–1530, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. N. S. Ryan and M. N. Rossor, “Correlating familial Alzheimers disease gene mutations with clinical phenotype,” Biomarkers in Medicine, vol. 4, no. 1, pp. 99–112, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. R. E. Tanzi and L. Bertram, “New frontiers in Alzheimer's disease genetics,” Neuron, vol. 32, no. 2, pp. 181–184, 2001. View at Publisher · View at Google Scholar · View at Scopus
  4. T. Zetzsche, D. Rujescu, J. Hardy, and H. Hampel, “Advances and perspectives from genetic research: development of biological markers in Alzheimers disease,” Expert Review of Molecular Diagnostics, vol. 10, no. 5, pp. 667–690, 2010. View at Publisher · View at Google Scholar
  5. S. A. Ropacki and D. V. Jeste, “Epidemiology of and risk factors for psychosis of Alzheimer's disease: a review of 55 studies published from 1990 to 2003,” American Journal of Psychiatry, vol. 162, no. 11, pp. 2022–2030, 2005. View at Publisher · View at Google Scholar · View at Scopus
  6. C. G. Ballard, S. Gauthier, J. L. Cummings et al., “Management of agitation and aggression associated with alzheimer disease,” Nature Reviews Neurology, vol. 5, no. 5, pp. 245–255, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. K. J. Reinikainen, H. Soininen, and P. J. Riekkinen, “Neurotransmitter changes in Alzheimer's disease: implications to diagnostics and therapy,” Journal of Neuroscience Research, vol. 27, no. 4, pp. 576–586, 1990. View at Publisher · View at Google Scholar · View at Scopus
  8. J. D. A. Olivier, L. A. W. Jans, A. Blokland et al., “Serotonin transporter deficiency in rats contributes to impaired object memory,” Genes, Brain and Behavior, vol. 8, no. 8, pp. 829–834, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. O. J. Robinson, R. Cools, M. J. Crockett, and B. J. Sahakian, “Mood state moderates the role of serotonin in cognitive biases,” Journal of Psychopharmacology, vol. 24, no. 4, pp. 573–583, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. K. P. Lesch, U. Balling, J. Gross et al., “Organization of the human serotonin transporter gene,” Journal of Neural Transmission, vol. 95, no. 2, pp. 157–162, 1994. View at Google Scholar · View at Scopus
  11. M. Nakamura, S. Ueno, A. Sano, and H. Tanabe, “The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants,” Molecular Psychiatry, vol. 5, no. 1, pp. 32–38, 2000. View at Google Scholar · View at Scopus
  12. A. Heils, A. Teufel, S. Petri et al., “Allelic variation of human serotonin transporter gene expression,” Journal of Neurochemistry, vol. 66, no. 6, pp. 2621–2624, 1996. View at Google Scholar · View at Scopus
  13. T. Li, C. Holmes, P. C. Sham et al., “Allelic functional variation of serotonin transporter expression is a susceptibility factor for late onset Alzheimer's disease,” NeuroReport, vol. 8, no. 3, pp. 683–686, 1997. View at Google Scholar · View at Scopus
  14. P. Zill, F. Padberg, S. de Jonge et al., “Serotonin transporter (5-HTT) gene polymorphism in psychogeriatric patients,” Neuroscience Letters, vol. 284, no. 1-2, pp. 113–115, 2000. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Hu, W. Retz, M. Baader et al., “Promoter polymorphism of the 5-HT transporter and Alzheimer's disease,” Neuroscience Letters, vol. 294, no. 1, pp. 63–65, 2000. View at Publisher · View at Google Scholar · View at Scopus
  16. D. Micheli, C. Bonvicini, A. Rocchi et al., “No evidence for allelic association of serotonin 2A receptor and transporter gene polymorphisms with depression in Alzheimer disease,” Journal of Alzheimer's Disease, vol. 10, no. 4, pp. 371–378, 2006. View at Google Scholar · View at Scopus
  17. D. Seripa, M. Franceschi, G. D'Onofrio et al., “Polymorphism C in the serotonin transporter gene (SLC6A4) in questionable dementia and Alzheimer's disease,” Neuroscience Letters, vol. 438, no. 3, pp. 335–339, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Grünblatt, S. Zehetmayer, J. Bartl et al., “Genetic risk factors and markers for Alzheimer's disease and/or depression in the VITA study,” Journal of Psychiatric Research, vol. 43, no. 3, pp. 298–308, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. C. Lorenzi, A. Marcone, A. Pirovano et al., “Serotonin transporter and saitohin genes in risk of Alzheimer's disease and frontotemporal lobar dementia: preliminary findings,” Neurological Sciences, vol. 31, no. 6, pp. 741–749, 2010. View at Publisher · View at Google Scholar
  20. L. Bertram, M. B. McQueen, K. Mullin, D. Blacker, and R. E. Tanzi, “Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database,” Nature Genetics, vol. 39, no. 1, pp. 17–23, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. J. R. Wendland, B. J. Martin, M. R. Kruse, K. P. Lesch, and D. L. Murphy, “Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531,” Molecular Psychiatry, vol. 11, no. 3, pp. 224–226, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. L. A. Hindorff, H. A. Junkins, P. N. Hall, J. P. Mehta, and T. A. Manolio, “A catalog of published genome-wide association studies,” January 2011, http://www.genome.gov/gwastudies/index.cfm?pageid=26525384#searchForm.
  23. G. McKhann, D. Drachman, and M. Folstein, “Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease,” Neurology, vol. 34, no. 7, pp. 939–944, 1984. View at Google Scholar
  24. V. C. Hachinski, L. D. Iliff, and E. Zilhka, “Cerebral blood flow in dementia,” Archives of Neurology, vol. 32, no. 9, pp. 632–637, 1975. View at Google Scholar
  25. M. F. Folstein, S. E. Folstein, and P. R. McHugh, “‘Mini mental state’. A practical method for grading the cognitive state of patients for the clinician,” Journal of Psychiatric Research, vol. 12, no. 3, pp. 189–198, 1975. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Albani, I. Roiter, V. Artuso et al., “Presenilin-1 mutation E318G and familial Alzheimer's disease in the Italian population,” Neurobiology of Aging, vol. 28, no. 11, pp. 1682–1688, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. K. J. Preacher, “Calculation for the chi-square test: an interactive calculation tool for chi-square tests of goodness of fit and independence,” [Computer software], April 2001.
  28. J. Cohen, Statistical Power Analysis for the Behavioral Sciences, Academic Press, New York, NY, USA, 1st edition, 1969.
  29. R. J. Davidson, K. M. Putnam, and C. L. Larson, “Dysfunction in the neural circuitry of emotion regulation—a possible prelude to violence,” Science, vol. 289, no. 5479, pp. 591–594, 2000. View at Publisher · View at Google Scholar · View at Scopus
  30. N. Bhana and C. M. Spencer, “Risperidone. A review of its use in the management of the behavioural and psychological symptoms of dementia,” Drugs and Aging, vol. 16, no. 6, pp. 451–471, 2000. View at Google Scholar · View at Scopus
  31. D. Albani, F. Prato, C. Fenoglio et al., “Association study to evaluate the serotonin transporter and apolipoprotein E genes in frontotemporal lobar degeneration in Italy,” Journal of Human Genetics, vol. 53, no. 11-12, pp. 1029–1033, 2008. View at Publisher · View at Google Scholar · View at Scopus