Neuroimaging Measures as Endophenotypes in Alzheimer's Disease
Figure 1
Common genetic variants (single nucleotide polymorphisms) associated with temporal lobe volume in a GWA study are shown in (a) along with an image showing the effects of the top hit, GRIN2b, on brain volume [81].The figure is adapted from Stein et al. (2010) with kind permission from the authors and publishers. (b) shows the effect (regression coefficients) of the candidate obesity gene, FTO, on brain atrophy in a cognitively normal adults and those with MCI and AD [76]. The figure is adapted from Ho et al. (2010) with kind permission from the authors and publishers.
