Figure 2: Portions of the complement cascade in relation to beta-amyloid processing: Alzheimer’s disease susceptibility genes returned from very large genomewide association studies are in black, and those from the pre-GWAS era in grey. Binding interactions are indicated by linked diamonds and other effects by arrows. C. Neo: Cryptococcus neoformans; C. Pneu: chlamydia pneumoniae; H. Pyl: Helicobacter pylori; P. Ging: Porphyromonas gingivalis; C1–C9: complement components. MAC: membrane attack complex. P-choline: phosphatidylcholine; black star: Herpes simplex: see text for details.