Mechanisms of Amyloid-Beta Peptide Uptake by Neurons: The Role of Lipid Rafts and Lipid Raft-Associated Proteins

Table 1

Summary of receptor proteins involved in the neuronal uptake of Aβ.

Receptor proteins involved in neuronal Aβ uptake
	Aβ binding	Aβ species	intracellular colocalization with Aβ	cell type where uptake was observed	endocytic pathway
Membrane receptors
NMDA receptor	probable	nonaggregated,; oligomeric	no data	hippocampal slices	clathrin-dependent
AMPA receptor	yes	Oligomeric	yes	hippocampal neurons	clathrin-dependent
integrins	yes	non-aggregated	no data	hippocampal slices	clathrin-dependent
𝛼7nChR	yes	non-aggregated	no data	neuroblastomas	both clathrin-dependent and independent
LRP1	via apoE	non-aggregated	no data	DRG neurons, neuroblastomas	clathrin-dependent
RAGE	yes	non-aggregated	no data	cortical neurons	no data
MEGF10	no data	non-aggregated	no data	neuroblastomas	raft-dependent/; caveolin-independent
Soluble receptors
apoE	yes	non-aggregated	yes	DRG neurons, neuroblastomas	clathrin-dependent, via LRP1
RAP	yes	non-aggregated	no data	neuroblastomas	no data