Increased plasma lipoprotein free Aβ42 in AD and Down Syndrome
Ann Neurol
Van Oijen
2006
8.6 Y Rotterdam study
1,756/6,713
Aβ40, Aβ42 Aβ42/Aβ40
396 cases developed dementia during follow up Increased Aβ40 level was a risk for onset of dementia Increased Aβ42/Aβ40 ratio decreased the risk for onset of dementia
Lancet Neurol
Graff-Radford
2007
3.7 Y Mayo Cohort
563 control
Aβ40, Aβ42 Aβ42/Aβ40
53 cases developed MCI and AD Significantly increased risk for onset of MCI and AD (3.1) in lower 25% group with decreased Aβ42/Aβ40 ratio
Arch Neurol
Schupf
2008
4.6 Y
1,125 control
Aβ40, Aβ42 Protofibrillar Aβ42
104 cases developed AD (9.2%) High Aβ42 level increased threefold risk for onset of AD Once developing AD, plasma Aβ42, Aβ42/Aβ40 ratio and protofibrillar Aβ42 were significantly decreased
PNAS
Xu
2008
—
113 AD 205 control
Autoantibody Aβ40, Aβ42
Anti-Aβ42 dimer antibody was absent in AD Aβ40/42 ratio increase with progression of AD
Brain Res
Lambert
2009
4 Y
233 dementia 958 control 8,414 source
Aβ40, Aβ42
prospective 3 city study Aβ42/Aβ40 ratio showed short-term risk of dementia
Neurol
Okereke
2009
10 Y prospective
481 Nurses
Aβ40, Aβ42
Presenile (mean 64 Y) high Aβ42/ Aβ40 ratio correlated with cognitive function 10 years later
