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International Journal of Alzheimer’s Disease
Volume 2011 (2011), Article ID 572495, 9 pages
Review Article

Potential Peripheral Biomarkers for the Diagnosis of Alzheimer's Disease

Banner Sun Health Research Institute, Sun City, AZ 85351, USA

Received 10 January 2011; Revised 17 August 2011; Accepted 25 August 2011

Academic Editor: Holly Soares

Copyright © 2011 Seema Patel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Advances in the discovery of a peripheral biomarker for the diagnosis of Alzheimer's would provide a way to better detect the onset of this debilitating disease in a manner that is both noninvasive and universally available. This paper examines the current approaches that are being used to discover potential biomarker candidates available in the periphery. The search for a peripheral biomarker that could be utilized diagnostically has resulted in an extensive amount of studies that employ several biological approaches, including the assessment of tissues, genomics, proteomics, epigenetics, and metabolomics. Although a definitive biomarker has yet to be confirmed, advances in the understanding of the mechanisms of the disease and major susceptibility factors have been uncovered and reveal promising possibilities for the future discovery of a useful biomarker.