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International Journal of Alzheimer’s Disease
Volume 2011, Article ID 607861, 7 pages
Research Article

Correlation of Copper Interaction, Copper-Driven Aggregation, and Copper-Driven H2O2 Formation with Aβ40 Conformation

1Institute of Life Science, Tzu Chi University, Hualien 970, Taiwan
2Department of Physics, National Dong Hwa University, Hualien 974, Taiwan
3Institute of Pharmacology, National Yang-Ming University, Shihpai, Taipei 112, Taiwan
4Institute of Molecular Biology, National Chung-Cheng University, Chiayi 621, Taiwan
5Department of Biochemistry and Molecular Biology, National Yang-Ming University, Shihpai, Taipei 112, Taiwan
6Department of Medical Research & Education, Taipei Veterans General Hospital, Shihpai, Taipei 112, Taiwan
7Department of Medicine, Mackay Medical College, Taipei County 252, Taiwan

Received 15 September 2010; Accepted 15 November 2010

Academic Editor: Craig Atwood

Copyright © 2011 Chia-Anne Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

As depicted in the Figure S1 of supplemental data (see Supplementary Material available online at doi:4061.2011/607861), the effect of TFE on the solubility of Cu2+ and the concentration of H2O2 was determined. Results clearly demonstrated that the main effect of TFE on the system is only to quench the DCF fluorescence intensity. Neither was the solubility of Cu2+ ions nor the formation of H2O2 affected by TFE.

  1. Supplementary Material