Figure 1: TrkB isoforms structure and functional domains. The extracellular portion of the receptor is conserved. The intracellular domain differs among the isoforms. TrkB FL contains a tyrosine kinase domain, a SHC-binding domain, and a PLC-γ-binding domain. TrkB SHC contains a SHC-binding domain and TrkB T does not have any functional domain.