TrkB Isoforms Differentially Affect AICD Production through Their Intracellular Functional Domains

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">Primers</td><td align="left">Sequence 5′ to 3′</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">TrkB.Y490F.F</td><td align="left">
									GTCATTGAAAACCCCCAGTTCTTCGGTATCACCAACAG</td></tr><tr><td align="left">TrkB.Y490F.R</td><td align="left">
									CTGTTGGTGATACCGAAGAACTGGGGGTTTTCAATGAC</td></tr><tr><td align="left">TrkB.Y816F.F</td><td align="left">
									GCGTCGCCCGTCTTCCTGGACATCCTAG </td></tr><tr><td align="left">TrkB.Y816F.R</td><td align="left">
									CGCAGCGGGCAGAAGGACCTGTAGGATC</td></tr><tr><td align="left">TrkB.Shc.F</td><td align="left">
									CTCAAGCCGGACACATGGCCCAGAGGTTCCCCCAAGACCGCCTGATAGTAATTTGTTCAGCACATC</td></tr><tr><td align="left">TrkB.Shc.R</td><td align="left">
									GATGTGCTGAACAAATTACTATCAGGCGGTCTTGGGGGAACCTCTGGGCCATGTGTCCGGCTTGAG</td></tr><tr><td align="left">TrkB K560M.F</td><td align="left">
									GGTGGCCGTGATGACGCTGAAGG</td></tr><tr><td align="left">TrkB K560M.R</td><td align="left">
									CCTTCAGCGTCATCACGGCCACC</td></tr><tr><td align="left">TrkB.SHC</td><td align="left">
									GTCATTGAAAACCCCCAGTTCTTCGGTATCACCAACAG</td></tr><tr><td align="left">TrkB.SHC</td><td align="left">
									CTGTTGGTGATACCGAAGAACTGGGGGTTTTCAATGAC</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

 Primer sequences used to obtain the point mutations and the sequence insertion on the TrkB FL receptor. The mutated bases are represented in bold.

International Journal of Alzheimer’s Disease

tab1

Table 1

Table 1: TrkB Isoforms Differentially Affect AICD Production through Their Intracellular Functional Domains 