Genomic Copy Number Analysis in Alzheimer's Disease and Mild Cognitive Impairment: An ADNI Study

Table 4

Genes that have CNV calls from at least one Alzheimer's disease (AD) and/or one mild cognitive impairment (MCI) participant and no healthy controls using the candidate gene approach.

Chromosome	Region	Start (bp)	End (bp)	Number of AD participants	APOE genotype	Age at onset^a	Number of MCI participants	APOE genotype
5	PPP2R2B	145949260	146441226	1	e3/e3	N/A	0	—
6	ATXN1	16407321	16869700	1	e3/e4	83 years	0	—
7	MAGI2	77484309	78920826	1	e2/e4	N/A	0	—
7	RELN	102899472	103417198	0	—	—	1	e4/e4
9	GRIN3A	103371455	103540683	1	e3/e3	74 years	0	—
10	LRRTM3	68355797	68530873	1	e3/e3	55 years	0	—
10	LIPA	90963305	91001640	0	—	—	1^b	e3/e3
12	PPM1H	61324030	61614932	1	e2/e3	N/A	1	e2/e3
15	CHRFAM7A	28440734	28473156	2	e3/e3	N/A	2	e3/e3
					e3/e4	N/A		e3/e4
15	ADAM10	56675801	56829469	1	e3/e3	N/A	1^b	e3/e3
21	DNAJC28	33782107	33785893	1	e3/e4	74 years	0	—
21	DOPEY2	36458708	36588442	0	—	—	1	e3/e4
22	GSTT1	22706138	22714284	1	e3/e3	59 years	0	—

^aAge at onset of AD symptoms, available only for participants with a baseline diagnosis of AD; N/A: Not available.
^bThe same participant had CNV calls overlapping the two genes.