Genetic Association between Akt1 Polymorphisms and Alzheimer's Disease in a Japanese Population

Table 3

A case-control haplotype analysis for the 6 Akt1 SNPs.

Haplotype	Overall	AD	Control	Chi-square	𝑃 value	Permutation 𝑃 value
C-C-C-A-A-A	0.3067	0.3165	0.2969	0.2694	0.6038	0.603
C-C-C-G-A-A	0.2401	0.2818	0.1779	8.8385	2.95𝐸−03	0.008*
C-G-T-G-A-A	0.2378	0.2236	0.26	1.0827	0.2981	0.324
A-G-T-A-A-A	0.0658	0.0449	0.0919	5.4284	0.0198	0.044*
A-G-T-G-A-A	0.0549	0.0347	0.0856	7.2736	7.00𝐸−03	0.028*

Rare haplotypes with frequencies less than 5% are not shown.
Each nucleotide on the haplotypes represents the SNPs in the following order from left to right: rs1130214 to rs7140735.
𝑃^∗<0.05: Statistically significant.