International Journal of Alzheimer’s Disease

Review Article

Introducing Human APOE into Aβ Transgenic Mouse Models

Table 1

ApoE transgenic models. Summary of the effects induced by deletion of mouse apoE (apo ) or the introduction of h-apoE isoforms on markers of neuronal degeneration and behavior. Key: HC: hippocampus; CX: cortex; DG: dentate gyrus; ChAT: choline acetyl transferase; ICH: intracerebral hemorrhage; LTP: long-term potentiation; TR: targeted replacement (knock-in); F: female; M: male; m: month.
ApoE model[ApoE]NeurodegenerationBehavioral phenotypeGender effects on behaviorReferences
Apo NASpine density and dendritic length:
WT > KO (HC/DG, 12 m)		Water maze:
WT > KO (6 m, F and M)		Water maze:
M > F (6 m)		[15–21]
ChAT:
WT > KO (HC, 6 m, M)		Anxiety vertical exploratory:
KO > WT (6 m, F)
GFAP-apoEMatchedSpine length and density:
E3 > E4 (HC, 12 m)		Water maze:
E3 > E4 (6 m, F)		Water maze:
M > F (apoE4 only)		 [17, 22–24]
Radial arm maze:
E3 > E4 (11–14 m, M)
NSE-apoEMatchedSynaptophysin:
E3 > E4 (HC, 5 m)		Water maze:
E3 > E4 (6 m, F)		Water maze: M > F (apoE4 only, 6 m)
ChAT activity:
E3 > E4 = KO (12 m):		 [25–27]
Tau phosphorylation:
E4 > E3 (9 m)
Kainic acid induced neurodegeneration
Synaptophysin and MAP-2:
E3 > E4 = KO (CX, 5 m)		 [25]
ApoE-TR Spine density and length:
E3 > E4 (1, 3 and 12 m)		Water maze/Active Y maze avoidance:
E3 > E4 (15 m, F)		Water maze:
M > F (6 and 13 m)
Dendritic length and node number:
E3 > E4 (1 m)		Anxiety elevated platform:
E4 > E3 (6–8 m, F)
EPSP interval:
E4/E4 > E2/E4 > E3/E3 (1 m)		 [18, 28–35]
LTP:
E3 > E4 (2–4 m)
ICH:
E4 > E3 (15 m+)
Vascular amyloid:
E4 > E3 (15 m+)