Amyloid Oligomer Neurotoxicity, Calcium Dysregulation, and Lipid Rafts
Figure 5
sCTOs and Aβ oligomers similarly damage the neuritic tree and synapses in mature hippocampal neurons. After sCTO or Aβ treatments, the extension of the dendritic tree, immunolabeled for microtubule-associated protein 2 (red fluorescence), is evidently reduced, while the number of synapses, immunolabeled for synaptophysin (green fluorescence), is decreased.
