Psychosis in Alzheimer's Disease in the National Alzheimer's Disease Coordinating Center Uniform Data Set: Clinical Correlates and Association with Apolipoprotein E
Table 1
Demographic and clinical characteristics and their association with AD+P.
Variable
Psychosis Status
Total (%) or mean (SD)
or
df
value
Never (%) or mean (SD)
Single (%) or mean (SD)
Multiple/Recurrent (%) or mean (SD)
Age
78.2 (6.8)
79.0 (7.1)
78.3 (7.1)
78.4 (6.9)
2.197‡
.111
Age of onset
73.3 (6.9)
73.4 (7.1)
72.3 (6.9)
73.2 (6.9)
2.862‡
.057
Sex
15.673†
2
<.001
Male
704 (46.5)
188 (38.1)
116 (37.5)
1008 (43.5)
Female
811 (53.5)
305 (61.9)
193 (62.5)
1309 (56.5)
Race
82.409†
4
<.001
Caucasian
1347 (89.0)
394 (80.0)
216 (70.0)
1957 (84.5)
African-American
132 (8.7)
76 (15.4)
69 (22.3)
277 (12.0)
Other
35 (2.3)
23 (4.6)
24 (7.7)
82 (3.5)
Hispanic
21.161†
2
<.001
No
1429 (94.3)
448 (90.9)
270 (87.4)
2147 (92.7)
Yes
86 (5.7)
45 (9.1)
39 (12.6)
170 (7.3)
Primary language
13.100†
2
.001
English
1425 (94.1)
455 (92.3)
273 (88.3)
2153 (92.9)
Other
90 (5.9)
38 (7.7)
36 (11.7)
164 (7.1)
Education
14.2 (3.6)
13.4 (3.6)
13.0 (4.2)
13.8 (3.7)
19.138‡
<.001
MMSE
18.7 (6.7)
16.8 (7.0)
14.2 (7.1)
17.7 (7.0)
59.922‡
<.001
CDR (global)
177.772†
8
<.001
0.0
12 (0.8)
0 (0.0)
0 (0.0)
12 (0.5)
0.5
364 (24.0)
52 (10.5)
12 (3.9)
428 (18.5)
1.0
583 (38.5)
192 (39.0)
83 (26.9)
858 (37.0)
2.0
408 (26.9)
182 (36.9)
132 (42.7)
722 (31.2)
3.0
148 (9.8)
67 (13.6)
82 (26.5)
297 (12.8)
Hachinski
1.1 (1.4)
1.1 (1.3)
1.3 (1.5)
1.1 (1.4)
2.417‡
.089
GDS
2.2 (2.4)
2.5 (2.8)
2.7 (3.0)
2.3 (2.6)
6.849‡
.001
APOE ϵ4 allele carrier status
4.008†
2
.135
−ϵ4
632 (41.7)
190 (38.5)
112 (36.2)
934 (40.3)
+ϵ4
883 (58.3)
303 (61.5)
197 (63.8)
1383 (59.7)
APOE ϵ4 allele number
5.097†
4
.277
0
632 (41.7)
190 (38.5)
112 (36.3)
934 (40.3)
1
712 (47.0)
236 (47.9)
158 (51.1)
1106 (47.7)
2
171 (11.3)
67 (13.6)
39 (12.6)
277 (12.0)
Abbreviations: AD+P, Alzheimer’s disease plus psychosis; MMSE, Mini-mental state exam; CDR, Clinical dementia rating scale; GDS, Geriatric depression scale; APOE, Apolipoprotein E. Pearson’s Chi-square test: values are presented. One-way analysis of variance: values are presented.
