Psychosis in Alzheimer's Disease in the National Alzheimer's Disease Coordinating Center Uniform Data Set: Clinical Correlates and Association with Apolipoprotein E
Table 4
Multinomial logistic regression analysis of Single and Multiple/Recurrent Psychosis when Never Psychotic (AD−P) cases were restricted to .
Psychosis category
Variable
OR
95% CI
Wald ()
value
Single
Age
1.022
(0.985, 1.061)
1.326
.250
Age of onset
0.980
(0.944, 1.017)
1.178
.278
Sex
0.833
(0.653, 1.063)
2.151
.143
Race
Caucasian
0.482
(0.236, 0.983)
4.028
.045
African-American
1.046
(0.476, 2.297)
0.013
.911
Othera
Hispanic origin
0.590
(0.295, 1.178)
2.234
.135
Primary language
1.699
(0.787, 3.670)
1.822
.177
Education
0.958
(0.924, 0.993)
5.583
.018
MMSE
1.016
(0.995, 1.036)
2.221
.136
Hachinski
0.966
(0.886, 1.053)
0.605
.437
GDS
1.053
(1.007, 1.101)
5.160
.023
APOE ϵ4 allele number
0
0.858
(0.592, 1.243)
0.655
.418
1
0.917
(0.641, 1.313)
0.223
.637
2a
Multiple/Recurrent
Age
1.052
(1.009, 1.098)
5.543
.019
Age of onset
0.929
(0.889, 0.969)
11.458
.001
Sex
0.876
(0.649, 1.182)
0.750
.387
Race
Caucasian
0.326
(0.153, 0.695)
8.438
.004
African-American
1.204
(0.523, 2.769)
0.190
.663
Othera
Hispanic origin
0.522
(0.237, 1.151)
2.597
.107
Primary language
1.030
(0.440, 2.408)
0.005
.946
Education
0.969
(0.930, 1.010)
2.274
.132
MMSE
0.947
(0.925, 0.968)
22.376
<.001
Hachinski
1.034
(0.942, 1.136)
0.499
.480
GDS
1.080
(1.026, 1.137)
8.692
.003
APOE ϵ4 allele number
0
0.883
(0.557, 1.398)
0.283
.595
1
1.087
(0.702, 1.685)
0.140
.709
2a
Abbreviations: AD−P, Alzheimer’s disease minus psychosis; MMSE, Mini-mental state exam; GDS, Geriatric depression scale; APOE, Apolipoprotein E.
aReference group.
