Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis
Tg-19959 mice exhibit increased proliferation in the dentate gyrus at all ages. We measured Ki67, a marker of cell proliferation in the dentate gyrus of wild type and Tg-19959 mice at different ages. There is significant increase in NSC proliferation in 5-week-old Tg-19959 mice (b) versus littermates wild type (a) that is maintained over time as animals aged (c). The markers of nestin (neural progenitor marker) and doublecortin (DCX, neuronal progenitor marker) were also significantly increased versus wild type in both mRNA (d) and protein (e) levels in hippocampus at all ages.
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