Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis
Effects of siLNA and sisiLNA in BACE1 and BACE1-AS RNA levels in vitro. To test the ability of siLNAs (a) and sisiLNAs (b) on BACE1 and BACE1-AS, we performed a study in mouse neuroblastoma N2a cells in vitro. Selective targets against BACE1-AS transcript were able to significantly knockdown not only BACE1-AS but also BACE1, supporting the proposed concordant regulation of BACE1 mRNA by BACE1-AS.
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