Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain

Table 3

Fold changes and 𝑃 values when comparing tg-ArcSwe mice and nontransgenic littermates and when comparing AD patients and control subjects (C).

Gene	Protein	Tg-ArcSwe versus nontransgenic				AD versus C
		Microarray		qPCR		qPCR
		Fold change	𝑃	Fold change	𝑃	Fold change	𝑃
CCND3	Cyclin D3	1.10	<.05	0.88	n.s.	1.14	n.s.
LEF1	Lymphoid enhancer-binding factor 1	0.92	<.05	0.88	n.s.	0.90	n.s.
MYC	V-myc myelocytomatosis viral oncogene homolog	1.09	<.05	0.91	n.s.	2.02	<.05
NFAT5	Nuclear factor of activated T-cells 5	0.91	<.05	0.96	n.s.	1.21	n.s.
NKD2	Naked cuticle homolog 2 (Drosophila)	1.08	<.05	1.05	n.s.	0.92	n.s.
PLCB1	Phospholipase C, beta 1	0.90	<.01	0.99	n.s.	0.82	n.s.
PPP2R2C	Protein phosphatase 2, regulatory subunit B, gamma	0.93	<.05	1.21	n.s.	1.24	n.s.
PPP3CB	Protein phosphatase 3, catalytic subunit	1.08	<.05	1.03	n.s.	0.79	n.s.
TCF7L2	Transcription factor 7-like 2	1.10	<.05	0.95	n.s.	1.43	<.05

n.s.: not significant.