Table of Contents Author Guidelines Submit a Manuscript
International Journal of Alzheimer’s Disease
Volume 2011 (2011), Article ID 939426, 5 pages
http://dx.doi.org/10.4061/2011/939426
Review Article

Biomarkers for Microglial Activation in Alzheimer's Disease

1Clinical Neurochemistry Laboratory, Department of Neurochemistry and Psychiatry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, 43180 Mölndal, Sweden
2Division of Alzheimer Neurobiology, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, 17177 Stockholm, Sweden

Received 30 June 2011; Accepted 1 September 2011

Academic Editor: Lucilla Parnetti

Copyright © 2011 Ronald Lautner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [19 citations]

The following is the list of published articles that have cited the current article.

  • Ryan Jalleh, Keith Koh, Boyoun Choi, Ebony Liu, John Maddison, and Mark R. Hutchinson, “Role of microglia and toll-like receptor 4 in the pathophysiology of delirium,” Medical Hypotheses, vol. 79, no. 6, pp. 735–739, 2012. View at Publisher · View at Google Scholar
  • Jonathan J. Sabbagh, Jefferson W. Kinney, and Jeffrey L. Cummings, “Alzheimer's disease biomarkers: Correspondence between human studies and animal models,” Neurobiology of Disease, vol. 56, pp. 116–130, 2013. View at Publisher · View at Google Scholar
  • Adriana Trapani, Claudio Palazzo, Modesto de Candia, Francesco Massimo Lasorsa, and Giuseppe Trapani, “Targeting of the Translocator Protein 18 kDa (TSPO): A Valuable Approach for Nuclear and Optical Imaging of Activated Microglia,” Bioconjugate Chemistry, pp. 130723141824000, 2013. View at Publisher · View at Google Scholar
  • Vyara Valkanova, Klaus P. Ebmeier, and Charlotte L. Allan, “CRP, IL-6 and depression: A systematic review and meta-analysis of longitudinal studies,” Journal of Affective Disorders, 2013. View at Publisher · View at Google Scholar
  • Helen Crehan, John Hardy, and Jennifer Pocock, “Blockage of CR1 prevents activation of rodent microglia,” Neurobiology of Disease, vol. 54, pp. 139–149, 2013. View at Publisher · View at Google Scholar
  • R. F. Frederiksen, D. K. Paspaliari, T. Larsen, B. G. Storgaard, M. H. Larsen, H. Ingmer, M. M. Palcic, and J. J. Leisner, “Bacterial chitinases and chitin-binding proteins as virulence factors,” Microbiology, vol. 159, no. Pt_5, pp. 833–847, 2013. View at Publisher · View at Google Scholar
  • Wesley M. Williams, Sandy Torres, Sandra L. Siedlak, Rudy J. Castellani, George Perry, Mark A. Smith, and Xiongwei Zhu, “Antimicrobial peptide beta-defensin-1 expression is upregulated in Alzheimer's brain,” Journal of Neuroinflammation, vol. 10, 2013. View at Publisher · View at Google Scholar
  • Henrik Zetterberg, and Kaj Blennow, “Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: More to Come?,” Journal of Alzheimers Disease, vol. 33, pp. S361–S369, 2013. View at Publisher · View at Google Scholar
  • Beatrice Mihaela Radu, Placido Bramanti, Francesco Osculati, Maria-Luisa Flonta, Mihai Radu, Giuseppe Bertini, and Paolo Francesco Fabene, “Neurovascular Unit in Chronic Pain,” Mediators of Inflammation, vol. 2013, pp. 1–18, 2013. View at Publisher · View at Google Scholar
  • Tanja Larsen, Yayoi Yoshimura, Bjørn G.R. Voldborg, Giuseppe Cazzamali, Nicolai V. Bovin, Ulrika Westerlind, Monica M. Palcic, and Jørgen J. Leisner, “Human chitotriosidase CHIT1 cross reacts with mammalian-like substrates,” FEBS Letters, 2014. View at Publisher · View at Google Scholar
  • Henrik Zetterberg, “Cerebrospinal fluid biomarkers for Alzheimer's disease: Current limitations and recent developments,” Current Opinion in Psychiatry, vol. 28, no. 5, pp. 402–409, 2015. View at Publisher · View at Google Scholar
  • Joel Jakobsson, Maria Bjerke, Sara Sahebi, Anniella Isgren, Carl Johan Ekman, Carl Sellgren, Bob Olsson, Henrik Zetterberg, Kaj Blennow, Erik Palsson, and Mikael Landen, “Monocyte and microglial activation in patients with mood-stabilized bipolar disorder,” Journal Of Psychiatry & Neuroscience, vol. 40, no. 4, pp. 250–258, 2015. View at Publisher · View at Google Scholar
  • Sindre Rolstad, Joel Jakobsson, Carl Sellgren, Anniella Isgren, Carl Johan Ekman, Maria Bjerke, Kaj Blennow, Henrik Zetterberg, Erik Pålsson, and Mikael Landén, “CSF neuroinflammatory Biomarkers in bipolar disorder are associated with cognitive impairment,” European Neuropsychopharmacology, 2015. View at Publisher · View at Google Scholar
  • Xi-Chen Zhu, Jin-Tai Yu, Teng Jiang, Ping Wang, Lei Cao, and Lan Tan, “CR1 in Alzheimer's Disease,” Molecular Neurobiology, vol. 51, no. 2, pp. 753–765, 2015. View at Publisher · View at Google Scholar
  • Ashley Swanson, and A.A. Willette, “Neuronal Pentraxin 2 predicts medial temporal atrophy and memory decline across the Alzheimer’s disease spectrum,” Brain, Behavior, and Immunity, 2016. View at Publisher · View at Google Scholar
  • Yu-Long Lan, Deng-Yang Fang, Jie Zhao, Tong-Hui Ma, and Shao Li, “A research update on the potential roles of aquaporin 4 in neuroinflammation,” Acta Neurologica Belgica, vol. 116, no. 2, pp. 127–134, 2016. View at Publisher · View at Google Scholar
  • Federico Licastro, and Elisa Porcellini, “Persistent infections, immune-senescence and Alzheimer's disease,” Oncoscience, vol. 3, no. 5-6, pp. 135–142, 2016. View at Publisher · View at Google Scholar
  • Sun Young Park, Young Hun Kim, and Geuntae Park, “Anti-neuro-inflammatory effects of Nardostachys chinensis in lipopolysaccharide-and lipoteichoic acid-stimulated microglial cells,” Chinese Journal of Natural Medicines, vol. 14, no. 5, pp. 343–353, 2016. View at Publisher · View at Google Scholar
  • Annie M. Racine, Tobey J. Betthauser, Catherine L. Gallagher, Howard A. Rowley, N. Maritza Dowling, Sanjay Asthana, Barbara B. Bendlin, Kaj Blennow, Henrik Zetterberg, Cynthia M. Carlsson, Bradley T. Christian, Rebecca L. Koscik, Sterling C. Johnson, Christopher R. Nicholas, Lindsay R. Clark, Ozioma C. Okonkwo, Jennifer M. Oh, Ansel T. Hillmer, Dhanabalan Murali, and Todd E. Barnhart, “Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β-amyloid accumulation,” Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, vol. 2, pp. 27–38, 2016. View at Publisher · View at Google Scholar