Simvastatin Blocks Blood-Brain Barrier Disruptions Induced by Elevated Cholesterol Both In Vivo and In Vitro
Figure 3
Simvastatin has no effect on high-cholesterol diet-induced downregulation of tight junction proteins. Images from Figure 2 were analyzed with Image J software. (a) Quantitative data from Figure 2(a) demonstrates that a high-cholesterol diet significantly decreases ZO-1 immunoreactivity in the olfactory bulbs and hippocampus, an effect that was not blocked by simvastatin. (b) Quantitative data from Figure 2(b) demonstrates that a high-cholesterol diet significantly decreased occludin immunoreactivity in the olfactory bulbs and hippocampus. However, this effect was not blocked by simvastatin treatment (5 mg/kg/day for 4 weeks) (, *).
