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International Journal of Alzheimer’s Disease
Volume 2012 (2012), Article ID 209570, 7 pages
http://dx.doi.org/10.1155/2012/209570
Clinical Study

Effects of Anosognosia on Perceived Stress and Cortisol Levels in Alzheimer’s Disease

1Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada H3T 1E2
2Center for Studies on Human Stress, Fernand-Seguin Research Center, Louis-H. Lafontaine Hospital, Montreal, QC, Canada H1N 3V2

Received 7 October 2011; Accepted 21 November 2011

Academic Editor: Kurt A. Jellinger

Copyright © 2012 Genevieve Arsenault-Lapierre et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Kirschbaum and D. H. Hellhammer, “Salivary cortisol in psychobiological research: an overview,” Neuropsychobiology, vol. 22, no. 3, pp. 150–169, 1989. View at Google Scholar
  2. S. S. Dickerson and M. E. Kemeny, “Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research,” Psychological Bulletin, vol. 130, no. 3, pp. 355–391, 2004. View at Publisher · View at Google Scholar · View at Scopus
  3. E. Steeman, B. D. De Casterlé, J. Godderis, and M. Grypdonck, “Living with early-stage dementia: a review of qualitative studies,” Journal of Advanced Nursing, vol. 54, no. 6, pp. 722–738, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. L. Clare, J. Rowlands, E. Bruce, C. Surr, and M. Downs, “The experience of living with dementia in residential care: an interpretative phenomenological analysis,” Gerontologist, vol. 48, no. 6, pp. 711–720, 2008. View at Google Scholar · View at Scopus
  5. B. D. Carpenter, C. Xiong, E. K. Porensky et al., “Reaction to a dementia diagnosis in individuals with Alzheimer's disease and mild cognitive impairment,” Journal of the American Geriatrics Society, vol. 56, no. 3, pp. 405–412, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. R. S. Lazarus and S. Folkman, Stress, Appraisal, and Coping, Springer, New York, NY, USA, 1984.
  7. A. Vogel, S. G. Hasselbalch, A. Gade, M. Ziebell, and G. Waldemar, “Cognitive and functional neuroimaging correlates for anosognosia in mild cognitive impairment and Alzheimer's disease,” International Journal of Geriatric Psychiatry, vol. 20, no. 3, pp. 238–246, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. C. H. Y. Wong, L. C. W. Lam, V. W. C. Lui, H. F. K. Chiu, S. S. M. Chan, and C. W. C. Tam, “Subjective complaints and self-evaluation of memory test performancen in Questionable dementia,” International Journal of Geriatric Psychiatry, vol. 21, no. 10, pp. 937–944, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. F. Galeone, S. Pappalardo, S. Chieffi, A. Iavarone, and S. Carlomagno, “Anosognosia for memory deficit in amnestic mild cognitive impairment and Alzheimer's disease,” International Journal of Geriatric Psychiatry, vol. 26, no. 7, pp. 695–701, 2011. View at Publisher · View at Google Scholar
  10. B. Reisberg, B. Gordon et al., “Insight and denial accompanying progressive cognitive decline in normal aging and Alzheimer’s disease,” in Geriatric Psychiatry: Ethical and Legal Issues, American Psychiatric Press, S. B. Washington, DC, USA, 1985. View at Google Scholar
  11. S. Cohen, T. Kamarck, and R. Mermelstein, “A global measure of perceived stress,” Journal of Health and Social Behavior, vol. 24, no. 4, pp. 385–396, 1983. View at Google Scholar · View at Scopus
  12. S. Cohen and G. Williamson, “Perceived Stress in a Probability Sample of the United States,” in The Social Psychology of Health, S. Spacapan and S. Oskamp, Eds., pp. 31–67, Sage, Newbury Park, Calif, USA, 1988. View at Google Scholar
  13. H. Wahbeh, S. S. Kishiyama, D. Zajdel, and B. S. Oken, “Salivary cortisol awakening response in mild Alzheimer disease, caregivers, and noncaregivers,” Alzheimer Disease and Associated Disorders, vol. 22, no. 2, pp. 181–183, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. W. B. Malarkey, D. K. Pearl, L. M. Demers, J. K. Kiecolt-Glaser, and R. Glaser, “Influenece of academic stress and season on 24-hour mean concentrations of ACTH, cortisol, and β-endorphin,” Psychoneuroendocrinology, vol. 20, no. 5, pp. 499–508, 1995. View at Publisher · View at Google Scholar · View at Scopus
  15. J. C. Pruessner, D. H. Hellhammer, and C. Kirschbaum, “Burnout, perceived stress, and cortisol responses to awakening,” Psychosomatic Medicine, vol. 61, no. 2, pp. 197–204, 1999. View at Google Scholar · View at Scopus
  16. M. Van Eck, H. Berkhof, N. Nicolson, and J. Sulon, “The effects of perceived stress, traits, mood states, and stressful daily events on salivary cortisol,” Psychosomatic Medicine, vol. 58, no. 5, pp. 447–458, 1996. View at Google Scholar · View at Scopus
  17. L. Murphy, R. Denis, C. P. Ward, and J. L. Tartar, “Academic stress differentially influences perceived stress, salivary cortisol, and immunoglobulin-A in undergraduate students,” Stress, vol. 13, no. 4, pp. 365–370, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. B. Garner, C. Phassouliotis, L. J. Phillips et al., “Cortisol and dehydroepiandrosterone-sulphate levels correlate with symptom severity in first-episode psychosis,” Journal of Psychiatric Research, vol. 45, no. 2, pp. 249–255, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Migliorelli, A. Teson, L. Sabe et al., “Anosognosia in Alzheimer's disease: a study of associated factors,” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 7, no. 3, pp. 338–344, 1995. View at Google Scholar · View at Scopus
  20. R. C. Petersen, G. E. Smith, S. C. Waring, R. J. Ivnik, E. Kokmen, and E. G. Tangelos, “Aging, memory, and mild cognitive impairment,” International Psychogeriatrics, vol. 9, no. 1, pp. 65–69, 1997. View at Google Scholar · View at Scopus
  21. G. McKhann, D. Drachman, and M. Folstein, “Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease,” Neurology, vol. 34, no. 7, pp. 939–944, 1984. View at Google Scholar · View at Scopus
  22. M. F. Folstein, S. E. Folstein, and P. R. McHugh, ““Mini mental state”. A practical method for grading the cognitive state of patients for the clinician,” Journal of Psychiatric Research, vol. 12, no. 3, pp. 189–198, 1975. View at Publisher · View at Google Scholar · View at Scopus
  23. Z. S. Nasreddine, N. A. Phillips, V. Bédirian et al., “The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment,” Journal of the American Geriatrics Society, vol. 53, no. 4, pp. 695–699, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. K. R. Greenop, J. Xiao, O. P. Almeida et al., “Awareness of cognitive deficits in older adults with cognitive-impairment-no-dementia (CIND): comparison with informant report,” Alzheimer Disease & Associated Disorders, vol. 25, no. 1, pp. 24–33, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. M. D. Orfei, A. E. Varsi, C. Blundo et al., “Anosognosia in mild cognitive impairment and mild alzheimer's disease: frequency and neuropsychological correlates,” American Journal of Geriatric Psychiatry, vol. 18, no. 12, pp. 1133–1140, 2010. View at Publisher · View at Google Scholar
  26. E. Salmon, P. Ruby, D. Perani et al., “Two aspects of impaired consciousness in Alzheimer's disease,” Progress in Brain Research, vol. 150, pp. 287–298, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. F. Clément, S. Belleville, and S. Gauthier, “Cognitive complaint in mild cognitive impairment and Alzheimer's disease,” Journal of the International Neuropsychological Society, vol. 14, no. 2, pp. 222–232, 2008. View at Publisher · View at Google Scholar · View at Scopus
  28. K. L. Davis, B. M. Davis, and B. S. Greenwald, “Cortisol and Alzheimer's disease. I: Basal studies,” American Journal of Psychiatry, vol. 143, no. 3, pp. 300–305, 1986. View at Google Scholar · View at Scopus
  29. F. Masugi, T. Ogihara, K. Sakaguchi et al., “High plasma levels of cortisol in patients with senile dementia of the Alzheimer's type,” Methods and Findings in Experimental and Clinical Pharmacology, vol. 11, no. 11, pp. 707–710, 1989. View at Google Scholar · View at Scopus
  30. K. Maeda, K. Tanimoto, T. Terada, T. Shintani, and T. Kakigi, “Elevated urinary free cortisol in patients with dementia,” Neurobiology of Aging, vol. 12, no. 2, pp. 161–163, 1991. View at Publisher · View at Google Scholar · View at Scopus
  31. F. Giubilei, F. R. Patacchioli, G. Antonini et al., “Altered circadian cortisol secretion in Alzheimer's disease: clinical and neuroradiological aspects,” Journal of Neuroscience Research, vol. 66, no. 2, pp. 262–265, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. G. Arsenault-Lapierre, H. Chertkow, and S. Lupien, “Seasonal effects on cortisol secretion in normal aging, mild cognitive impairment and Alzheimer's disease,” Neurobiology of Aging, vol. 31, no. 6, pp. 1051–1054, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Lind, A. Edman, A. Nordlund, T. Olsson, and A. Wallin, “Increased saliva cortisol awakening response in patients with mild cognitive impairment,” Dementia and Geriatric Cognitive Disorders, vol. 24, no. 5, pp. 389–395, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Baum and N. E. Grunberg, “Gender, stress, and health,” Health Psychol, vol. 10, no. 2, pp. 80–85, 1991. View at Google Scholar
  35. P. McDonough and V. Walters, “Gender and health: reassessing patterns and explanations,” Social Science & Medicine, vol. 52, no. 4, pp. 547–559, 2001. View at Google Scholar
  36. T. E. Seeman, B. Singer, C. W. Wilkinson, and B. McEwen, “Gender differences in age-related changes in HPA axis reactivity,” Psychoneuroendocrinology, vol. 26, no. 3, pp. 225–240, 2001. View at Publisher · View at Google Scholar
  37. Z. S. K. Lee, J. C. N. Chan, V. T. F. Yeung et al., “Plasma insulin, growth hormone, cortisol, and central obesity among young Chinese type 2 diabetic patients,” Diabetes Care, vol. 22, no. 9, pp. 1450–1457, 1999. View at Publisher · View at Google Scholar · View at Scopus
  38. I. Chiodini, S. Di Lembo, V. Morelli et al., “Hypothalamic-pituitary-adrenal activity in type 2 diabetes mellitus: role of autonomic imbalance,” Metabolism, vol. 55, no. 8, pp. 1135–1140, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. H. Bruehl, M. Rueger, I. Dziobek et al., “Hypothalamic-pituitary-adrenal axis dysregulation and memory impairments in type 2 diabetes,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 7, pp. 2439–2445, 2007. View at Publisher · View at Google Scholar · View at Scopus